An intense form of ultrasound that shakes a tumor until its cells start to leak can trigger an “alarm” that enlists immune defenses against the cancerous invasion, according to a study led by researchers at Duke University's Pratt School of Engineering.
The new findings from animal experiments suggest that once activated by the ultrasound, the immune system might even seek and destroy cancer cells, including those that have spread through the bloodstream to lurk in other parts of the body.
This high-intensity focused ultrasound, or HIFU, is in use or testing in China, Europe and the United States to kill tumors by heating them. But Duke researchers now find that HIFU might work even better if it is first delivered in a manner that just shakes the cells.