Several neurological and psychiatric disorders, including schizophrenia, alcoholism, and Parkinson’s disease, are associated with changes in the brain that affect the nerves that communicate with each other through the naturally-produced chemical dopamine. One protein that is crucial for dopamine-mediated neuronal communication in animals is DARPP-32. However, very little is known about the function of this protein in humans.

In a study appearing online on February 8 in advance of publication in the March print issue of the Journal of Clinical Investigation, Daniel Weinberger and colleagues from the National Institutes of Health show that the gene that encodes DARPP-32 exhibits genetic variation.

Light has been shed on the dark parts of the Moon with experiments by University of Edinburgh researchers simulating billions of years of lunar evolution.

It is generally believed the Moon was created after an early, semi molten, Earth collided with a planet the size of Mars.

The collision was so great that the orbiting debris would have formed a so-called lunar magma ocean, or liquefied rock, up to several hundred kilometres deep that would have covered the Moon's surface.

Yet until now, it has remained a mystery as to how this magma ocean cooled and how the lunar landscape evolved into white highlands and dark valleys.

Researchers at the University of Illinois at Urbana-Champaign have developed a novel computational image-forming technique for optical microscopy that can produce crisp, three-dimensional images from blurry, out-of-focus data.

Called Interferometric Synthetic Aperture Microscopy, ISAM can do for optical microscopy what magnetic resonance imaging did for nuclear magnetic resonance, and what computed tomography did for X-ray imaging, the scientists say.


Photo courtesy of Beckman Institute
Representations of a tissue phantom where the scattering points
would represent cells, and images before and after ISAM are shown.

Video games that contain high levels of action, such as Unreal Tournament, can actually improve your vision.

Researchers at the University of Rochester have shown that people who played action video games for a few hours a day over the course of a month improved by about 20 percent in their ability to identify letters presented in clutter—a visual acuity test similar to ones used in regular ophthalmology clinics.

In essence, playing video game improves your bottom line on a standard eye chart.


Perhaps Daphne Bavelier and Shawn Green will work on reasons to skip school and eat Fritos next. (Image courtesy of University of Rochester)

As I plan to become a clinical geneticist, I should write more often about genetic conditions. But I don't want to duplicate the articles of Wikipedia, my aim is to provide useful sources of information. Pompe disease is a rare disorder caused by the deficiency of the acid alpha-glucosidase enzyme. It's inherited in an autosomal recessive manner. The patients can't break down glycogen. According to the Wiki article:

A giant elliptical galaxy seen in an image from the Hubble Space Telescope is the closest gravitational lens yet known, according to information released by the Hubble Heritage Project Tuesday (Feb. 6).

John Blakeslee, an assistant professor with the Department of Physics and Astronomy at Washington State University, working with colleagues from the University of Hawaii and the University of Durham in England, targeted the galaxy for a closer look by Hubble.

Elliptical Galaxy ES) 325-G004 in the Abell Cluster S0740. (Credit: NASA, ESA, and The Hubble Heritage Team (STScI/AURA) / Acknowledgment: J. Blakeslee (Washington State University))

A greenhouse gas that has become the bane of modern society may have saved Earth from completely freezing over early in the planet's history, according to the first detailed laboratory analysis of the world's oldest sedimentary rocks.

Scientists have for years theorized that high concentrations of greenhouse gases could have helped Earth avoid global freezing in its youth by allowing the atmosphere to retain more heat than it lost.

 

In January, I spent two weeks attending the world’s largest consumer technology convention and a much smaller but very important annual television convention.  This column is to give you an idea of what will new cutting edge gadgets will soon be available and to also suggest ways they will affect how you consume media and access information.

Many human proteins are not as good as they might be because the gene sequences that code for them have a double role which slows down the rate at which they evolve, according to new research published in PLoS Biology.

By tweaking these dual role regions, scientists could develop gene therapy techniques that produce proteins that are even better than those found in nature, and could one day be used to help people recover from genetic disorders.

The stretch of DNA which codes for a specific protein is often interrupted by sections of apparently useless DNA – known as introns – which need to be edited out in order to produce a new protein.


Before a transcribed gene is translated into t