Reported: a 42 year old female patient with a serious atopic dermatitis, abruptly appearing since age 8. During several hospitalizations, the patient underwent various therapies without reaching -she relates- any amelioration but on the other hand getting bad influences on the relationship, due to the deep hormonal diseases induced by the cortico therapy. Kept under observation from october 1995, the patient was subjected to an increasing treatment with cyclosporine, starting with a 2,5 mg/Kg/die at the end of an 8 months timeframe archiving a total recovery of the cutaneous pathology and being enabled to a normal social life.

The first case of progressive scalp cicatricial alopecia and
follicular lichen planus (LP) on the trunk and extremities, was
described by Piccardi in 1914, to which he gave the name
"cheratosi spinulosa".

Graham-Little published a similar case in
the successive year of a 55 year old woman, referred by Lasseur of
Lausanne,Switzerland. LASSUEUR PICCARDI GRAHAM LITTLE Syndrome is a rare case where are associated "Cicatricial alopecia and lichen planus follicularis" come together small confluent patches of progressive scarring alopecia, appearance of the lichen planus follicularis with follicular keratosis and noncicatricial alopecia of the axilae and pubes.

Malignant Melanoma is the most aggressive of malignant cutaneous tumours. Cases with lymphonode involvement, and distant metastases, carry a very poor prognosis, (50% and 20% respectively alive in 5 years), while those presenting without evident lymphonode involvement have a much better survival rate (60% alive in 5 years).

It is therefore extremely important to do early malignant melanoma diagnosis. There are several criteria that may lead to the diagnosis of a malignant melanoma. The most important one is the ABCD rule.

The ABCD diagnosis of Malignant Melanoma -

The case of a 47 year-old woman presenting a wide abdominal zone with vitiligo like hypopigmentation is reported.

In 1977 she underwent, in the same site, melanoma (III Clarke's level) extirpation and local immunotherapy by DNCB ( dinitrochlorobenzene ).

Moshe Inbar et Al. ( Melanoma Research 1996/6/457-459 ) refers a case of melanoma, treated by DNCB in 1973, showing, the new skin, over the back, characterized by vitiligo like hypopigmentation and lack of hair.

In people affected by acquired immuno-deficiency syndrome it may often be observed a rise of cutaneous emergencies, whose impact spans from 25% in asyntomatic subjects to 100% in the case of very evident AIDS.

The frequency and the atypic nature of these emergencies gives a highlighted role to the dermatologist, characterizing the early diagnosis of cutaneous pathologies as the qualifying moment in the analysis of AIDS affected patient.

As the starting moment in the HIV-positive subject examination, search for injuries referable to Kaposi's sarcoma, especially at the mucous level (pharinx wounds are evident in 10 to 50% of total cases).

Introduction: Bioterrorism is the utilization of microorganisms or toxins in order to produce a disease and/or death in human beings, animals or plants. Different from conventional weaponry, relatively economic means are used that allow the elimination of living beings without destroying the surrounding atmosphere.

The most probably method for spread of bioweapons is aerial transmission, continuing into water supplies and food. The CDC (US Centers for Disease Control and Prevention, Atlanta) has subdivided into three categories the aggressiveness of "Bioweapons".

Category A comprises: