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Melville on Science vs. Creation Myth

From Melville's under-appreciated Mardi: On a quest for his missing love Yillah, an AWOL sailor...

Non-coding DNA Function... Surprising?

The existence of functional, non-protein-coding DNA is all too frequently portrayed as a great...

Yep, This Should Get You Fired

An Ohio 8th-grade creationist science teacher with a habit of branding crosses on his students'...

No, There Are No Alien Bar Codes In Our Genomes

Even for a physicist, this is bad: Larry Moran, in preparation for the appropriate dose of ridicule...

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Michael WhiteRSS Feed of this column.

Welcome to Adaptive Complexity, where I write about genomics, systems biology, evolution, and the connection between science and literature, government, and society.

I'm a biochemist

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As a book junkie, I love to get and give book recommendations. Here is my Darwin Day recommended books list:

What Evolution Is, Ernst Mayr - My favorite brief, single-volume primer on evolution for non-specialists.

“What does the body of a professor share with a blob?” Neil Shubin answers this and other questions about the evolutionary history of our anatomy in Your Inner Fish: A Journey Into The 3.5-Billion-Year History of the Human Body (Pantheon, 2008).

As an undergraduate student considering a research career in science, I once endured a 7 AM human anatomy course. In my semi-conscious state, breathing the slightly disturbing fumes of the preservative that the teaching assistant kept spraying on the cadavers, I was thinking, ‘this is morbidly fascinating, but really not that relevant to what scientists do today.’

If Neil Shubin had been teaching my anatomy course, I wouldn’t have struggled to get out of bed and make it to class on time. His book is a fun, compelling tour of the evolutionary history of the human body, filled with dozens of examples that nicely illustrate why our anatomy only makes real sense when it is understood in the context of evolution.

I'm trying to find time to write a paper, and thus I've neglected my blog. But here are two interesting links: Super Tuesday and Science Debate 2008: The US National Academies of Sciences have joined in the call for a US Presidential Election Science Debate. The National Academies have offered to co-sponsor this event. If you haven't heard of this movement yet, go check it out. One of the pioneers of molecular biology, Nobel Laureate Joshua Lederberg, passed away this past weekend.
The late Leslie Orgel, a pioneering researcher in pre-biotic evolution, has an interesting essay in the most recent issue of PLoS Biology. A long-running debate in origins-of-life research has been over what came first: genetic material, or a self-organizing metabolism. The self-organizing metabolism theory has been most prominently argued by Stuart Kauffman. Orgel doesn't rebut Kauffman's theoretical work, but he does claim it makes unrealistic assumptions about peptide chemistry, and thus is unlikely to be what happened on earth 4 billion years ago.
A group of the world's leading sequencing centers have announced plans to sequence 1000 human genomes. The cost of the first human genome project was about $3 billion; by comparison, the next 1000 will be a steal at possibly only $50 million dollars (and that's total cost, not per genome). But that's still a lot of money - why are we investing so much in sequencing genomes? It may be a lot up front, but the benefits, in terms of both economics and medical research, easily outweigh the cost of such a large project. By pooling sequencing resources and making large amounts of genome sequence data available up front, we can avoid inefficient and redundant sequencing efforts by groups of independent research groups trying discover gene variants involved in disease. In fact, it would probably be worthwhile to sequence 10,000 human genomes. With 1000 genomes, we're at least making a good start.
Richard Feynman on Doubt [Fill in she instead of he as appropriate...] "The scientist has a lot of experience with ignorance and doubt and uncertainty, and this experience is of very great importance, I think. When a scientist doesn't know the answer to a problem, he is ignorant. When he has a hunch as to what the result is, he is uncertain. And when he is pretty damn sure of what the result is going to be, he is in some doubt." A scientific theory that withstands that kind of scrutiny for over a hundred years is a damn good theory. (Quote is from The Pleasure of Finding Things Out, p. 146 - the book, not the TV documentary transcript of the same name.)