A just completed clinical trial of K.Vita (Betashot), a dietary treatment for children and adults with severe forms of epilepsy, found it was well tolerated and reduced seizures.

The product was developed to offset the risks of the ketogenic diet, which mimics a fasting state by altering the metabolism to use body fat as the primary fuel source. Ketosis is when the body switches from carbohydrates to fat for body fuel.

It has shown some success with drug-resistant epilepsies but the restrictive high-fat, low-carbohydrate diet can cause constipation, low blood sugar, and stomach problems. 

Alternative polyadenylation (APA) is an RNA processing mechanism that regulates gene expression by generating different ends on RNA transcripts of the same gene. Though it affects more than half of human genes, the significance of APA was poorly understood.

Now a new study by The Wistar Institute describes an important function of APA in allowing certain mRNAs to reach specific sites of protein synthesis and reveals that length, sequence and structural properties can determine the destination (and fate) of mRNAs within the cell.

During the COVID-19 pandemic, wealthier people had the money to stay home and order online. Not so for poor people, who instead made more trips to local dollar stores and small groceries to get their family's food.

Why is that bad? It isn't at face value, supporting local businesses is an aspirational claim for many, but a group of academics claim that without equal incomes and equal access to buying in bulk, poor people were worse off when it comes to making healthy food choices. That is like arguing muffin in a local bodega is bad while a muffin in a Whole Foods is good, when experts know the Whole Foods version has far more calories. 

An unknown methane-producing process is likely at work in the hidden ocean beneath the icy shell of Saturn's moon Enceladus, suggests a new study published in Nature Astronomy by scientists at the University of Arizona and Paris Sciences&Lettres University.

In an observational study using data from the Veterans Health Administration for 2,344 U.S. veterans hospitalized with COVID-19, remdesivir treatment was associated with prolonged hospitalization but wasn't associated with improved survival. 

Adolescent girls and young women can and will use HIV prevention products with consistency, according to interim results of a study of two different methods: daily use of the antiretroviral (ARV) tablet Truvada® as oral pre-exposure prophylaxis (PrEP) and the monthly dapivirine vaginal ring, a new HIV prevention product currently under regulatory review in several countries.

To provide protection against HIV, both must be used consistently- daily, for oral PrEP, and for the ring, a full month at a time - which previous studies of these products found to be especially challenging for younger women.