Intradiscal biacuplasty is an effective procedure to treat chronic discogenic pain, report researchers at the 23rd annual meeting of the American Academy of Pain Medicine in New Orleans. Improvement in pain scores and functional capacity can be observed much earlier with intradiscal biacuplasty than with intradiscal electrothermal therapy suggesting some additional or/and different mechanisms of action. It also appears to be more effective than intradiscal electrothermal therapy producing more than 50% of the pain relief in more than 50% of patients.

Intradiscal electrothermal therapy has produced variable results in the pain reduction and functional improvement in patients with axial discogenic pain.

Whether in the form of sensors in the refrigerator which automatically order more milk or in the car sounding an alarm when the driver starts to become drowsy, "Ambient Intelligence" is the next computer technology revolution. But networked objects equipped with intelligence will only be able to establish themselves if they take proper consideration of users' misgivings, in particular with regard to data protection.

The mention of facial composites often conjures up images of a sinister criminal, skillfully depicted by a sketch artist using pencil and paper. In reality, the vast majority of law enforcement agencies use mechanized methods, usually computer software, when creating facial composite. By having a vast repertoire of eyes, ears, hair and so on at their disposal, witnesses have the ability to create an image that ideally encompasses all of the features of the perpetrator. So have these technological advances improved our ability to identify and apprehend criminals?

Findings published in Science will accelerate the search for genes involved in human disease. The report provides a first genome-wide view of how the unique composition of genetic variation within each of us leads to unique patterns of gene activity.

By defining those genetic variants with a biological effect, the results will help prioritise regions of the genome that are investigated for association with disease.

Using artificial atoms on a chip, Yale physicists have taken the next step toward quantum computing by demonstrating that the particle nature of microwave photons can now be detected, according to a report spotlighted in the February 1 issue of the journal Nature.

Quantum theories are often considered to apply best to processes that happen on the smallest scale of atoms and molecules. By making artificial atoms larger — to a size that is nearly visible — and using microwaves as the source of energy, the collaborative research from the laboratory of Professor Robert Schoelkopf and the theory group of Professor Steven Girvin in the departments of Applied Physics and Department of Physics at Yale created an electronic circuit that stores and measures individual microwave photons.

A robotic exoskeleton controlled by the wearer's own nervous system could help users regain limb function, which is encouraging news for people with partial nervous system impairment, say University of Michigan researchers.

The ankle exoskeleton developed at U-M was worn by healthy subjects to measure how the device affected ankle function.

People’s long-term satisfaction with their lives often parallels that of their spouse, says a University of Toronto researcher in a study that deals a blow to theories that individual happiness depends mainly on genetic disposition.

Ulrich Schimmack of the University of Toronto at Mississauga’s psychology department and Richard Lucas of the University of Michigan studied the similarity in life satisfaction of more than 800 German married couples. They found that individuals’ reports of increased or decreased life satisfaction closely matched those of their spouses over a period of 21 years.

Johns Hopkins Kimmel Cancer Center scientists have found a set of "master switches" that keep adult blood-forming stem cells in their primitive state. Unlocking the switches' code may one day enable scientists to grow new blood cells for transplant into patients with cancer and other bone marrow disorders.

The scientists located the control switches not at the gene level, but farther down the protein production line in more recently discovered forms of ribonucleic acid, or RNA.

In recent years, scientists have discovered that a family of enzymes called sirtuins can dramatically extend life in organisms as diverse as yeast, worms, and flies. They may also be able to control age-associated metabolic disorders, including obesity and type II diabetes.

Naturally occurring substances have been shown to activate sirtuins, including a constituent of red wine called resveratrol -- although an individual would need to drink about two cases of wine a day to derive a clinically effective dose of resveratrol. Still, the findings have energized a number of scientific groups and biotechnology companies, all of which are now eagerly searching for drug candidates able to boost sirtuin activity.