The combinatorial, multi-gene GeneSight test has been found to better predict antidepressant treatment outcomes for patients with depression, and their use of health care resources, than any of the individual genes that comprise the test, according to a peer-reviewed analysis by investigators from the Mayo Clinic and Assurex Health, and published online by The Pharmacogenomics Journal .

The proprietary technology of the GeneSight Psychotropic test is based on combinatorial pharmacogenomics (CPGx™), the study of how variations in multiple genes collaborate to influence an individual's response to medications, and evidence-based medicine and the known clinical pharmacology of various drugs.

When it comes to gene expression - the process by which our DNA provides the recipe used to direct the synthesis of proteins and other molecules that we need for development and survival - scientists have so far studied one single gene at a time. A new approach developed by Harvard geneticist George Church, Ph.D., can help uncover how tandem gene circuits dictate life processes, such as the healthy development of tissue or the triggering of a particular disease, and can also be used for directing precision stem cell differentiation for regenerative medicine and growing organ transplants.

A new study has found women who smoke when pregnant are putting their daughters at a greater risk of developing ovarian and breast cancer later in life.

The Australian National University (ANU) study, published in Human Reproduction, found mothers who reported smoking most days while pregnant had daughters who had an earlier age of first menstruation, or menarche.

Lead researcher Dr Alison Behie said reaching menarche at an earlier age increases the number of ovulation cycles a woman will have in her life, and puts her at greater risk of developing reproductive cancers possibly due to increased exposure to hormones such as oestrogen.

Temple University researchers have assembled the largest and most accurate tree of life calibrated to time, and surprisingly, it reveals that life has been expanding at a constant rate.

"The constant rate of diversification that we have found indicates that the ecological niches of life are not being filled up and saturated," said Temple professor S. Blair Hedges, a member of the research team's study, published in the early online edition of the journal Molecular Biology and Evolution. "This is contrary to the popular alternative model which predicts a slowing down of diversification as niches fill up with species."

Taking omega-3 fatty acids appeared to lower inflammation and guard against further declines in heart function among recent heart attack survivors already receiving optimal standard care, according to results from a randomized, controlled trial to be presented at the American College of Cardiology's 64th Annual Scientific Session in San Diego.

Drug testing is most commonly performed using urine samples and its accuracy has made it the gold standard, but collecting samples is inconvenient so a group of researchers from the Department of Laboratory Medicine at the Karolinska Institute in Sweden have been working on developing an alternative to urine testing that focuses on exhaled breath.

Professor Olof Beck, lead researcher of the study, and his team have developed the first fully validated and robust screening method for the routine measurement of drugs of abuse in exhaled breath. The procedure involves a simple method of sample collection and preparation, which is followed by a highly sensitive analytical technique known as LC-MS (Liquid chromatography-mass spectrometry).