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Of Mice And Men And Monkeys And - Aging

... restriction and CR mimetics concerns the molecule known as IGF-1, short for insulin-like growth factor. IGF-1 is critical in humans—we would die without it—because it helps ...

Article - Greg Critser - Jul 21 2009 - 10:40am - 0 attachments

Successful Phase I/II Clinical Trial Results From Cancer Patients Treated With Anti-Cancer Drug From Axelar AB

... anti-cancer drug AXL1717,an insulin-like growth factor-1 (IGF-1) receptor inhibitor which has no effects on the closely related insulin ... alternative for cancer patients in the future. The IGF-1 receptor is a promising target for the treatment of cancer, since the ...

Article - Anna Ohlden - May 6 2009 - 7:01am - 0 attachments

IGF-1 Growth Hormone No Benefit For ALS

... using growth hormone insulin-like growth factor-1, or IGF-1 , to treat ALS had conflicting results. A North American study found ... no benefit.  The current two-year study found that IGF-1 does not slow the progression of weakness in the disease. ALS, also ...

Article - News Staff - Nov 24 2008 - 8:18pm - 0 attachments

RAD001 Combined With Sandostatin(R) LAR(R) And As Monotherapy Controls Growth Of Rare Pancreatic Neuroendocrine Tumours

... and in many cases can normalize growth hormone and/or IGF-1 levels in patients with acromegaly, a disease caused by a pituitary ...

Article - Anna Ohlden - Sep 17 2008 - 8:32am - 0 attachments

Male Height Linked To Prostate Cancer Risk (Sort Of)

... this association could be the insulin-like growth factor-1(IGF-1) system, which stimulates cell growth and has been shown to be involved ...

Article - News Staff - Sep 3 2008 - 12:06am - 0 attachments

IGF-1: The Secret Of The Enlarged Hearts In Elite Rowers

... to have higher levels of insulin-like growth factor 1 (IGF-1) compared to healthy sedentary volunteers. In these athletes, IGF-1 values correlate with enlargement and strengthening of heart muscle cells. IGF-1 is a hormone that is produced by the liver in response to growth hormone ...

Article - News Staff - Aug 8 2008 - 12:53am - 0 attachments

FGF21 And Starving Our Way To Longevity

... stimulates creation of protein and increases levels of IGF-1 (insulin-like growth factor-1), a hormone that promotes growth. Too much ... span: growth hormone resistance, low concentrations of IGF-1, increased insulin sensitivity and small size." FGF21 is already ...

Article - News Staff - Jun 27 2008 - 4:07pm - 0 attachments

Axelar Initiates Phase I/II Clinical Trial On Cancer Patients With The New Anti-Cancer Drug AXl1717

... anti-cancer drug AXL1717, an insulin-like growth factor-1 (IGF-1) receptor inhibitor. The phase I/II clinical trial is primarily designed ... and exciting treatment alternative." About Cancer, the IGF-1 receptor and AXL1717 Globally more than 12 million people are ...

Article - Anna Ohlden - Jun 17 2008 - 6:33am - 0 attachments

Axelar Receives Financing For A Phase I/II Clinical Trial On Cancer Patients With The New Anti-Cancer Drug AXL1717

... I/II clinical trial with the insulin-like growth factor-1 (IGF-1) receptor inhibitor AXL1717 on cancer patients. Globally more than 12 ... for new and alternative anti-cancer therapies. The IGF-1 receptor is a promising target for treatment of cancer, since the IGF-1 ...

Article - Anna Ohlden - Jun 12 2008 - 6:32am - 0 attachments

Caloric Restriction - Mouse Study Says Dieting Is Better Than Exercise For Longevity

... had the highest levels of insulin-like growth factor (IGF-1), which plays a key role in regulating cell growth and cell death. The animals on caloric restriction had the lowest levels of IGF-1. Exercise also seemed to play an important role in regulating IGF-1 ...

Article - News Staff - May 13 2008 - 11:53pm - 0 attachments