Now that the genome sequences of hundreds of bacteria and viruses are known, we can design tests that will rapidly detect the presence of these species based solely on their DNA. These tests can detect a pathogen in a complex mixture of organic material by recognizing short, distinguishing sequences—called DNA signatures—that occur in the pathogen and not in any other species.
Adam Phillippy and colleagues from the University of Maryland, USA, have developed a computer program that can identify these signatures with a higher degree of accuracy than ever before. They describe this new computational system, called Insignia, and the results of its successful application on 46 Vibrio cholerae strains this week in the journal PLoS Computational Biology.