Termites know how to digest cellulose, but the human process of producing ethanol from cellulose is slow and expensive. The bottleneck is the rate at which the cellulose enzyme breaks down cellulose into sugars, which are then fermented into ethanol.
To help unlock the cellulose bottleneck, a team of scientists has conducted molecular simulations at the San Diego Supercomputer Center (SDSC), based at UC San Diego. By using "virtual molecules," they have discovered key steps in the intricate dance in which the enzyme acts as a molecular machine -- attaching to bundles of cellulose, pulling up a single strand of sugar, and putting it onto a molecular conveyor belt where it is chopped into smaller sugar pieces.