India is divided into several agroclimatic zones which differs in environmental, nutritional and edaphic conditions affecting plant growth and productivity. The Calotropis procera and Calotropis gigantea prefers their distribution and growth pattern in India. Detailed studies were carried out in different parts of the country to elucidate the influence of agroclimatic conditions on growth and productivity of C. procera and C. gigantea. The growth and productivity of C. procera is positively influenced by the condition of Jaisalmer with temperature 0-50°C and with low rainfall 5-10 ml/annum. The biocrude yield of C. procera varide 2.5-12% depending on the location. C. gigantea is very tall and grown largely under horticultural conditions as ornamental plant and has religious value that is why it is probably found in Shiv temples.