A fat-derived protein known for its effects on the liver and skeletal muscle might also serve as an energy-conserving signal to the brain during periods of starvation, suggests a new study.
The substance, known as adiponectin, acts on the brain to boost appetite and slow energy expenditure in an effort to maintain adequate fat stores during lean times, the researchers report.
“Energy homeostasis may be mediated by both short-term regulators, such as gut hormones, and long-term regulators,” said Takashi Kadowaki of the University of Tokyo. “In this study, we identified, for the first time, a potential long-term regulator that allows energy to be stored efficiently, namely, adiponectin.”