The cancer drug asparaginase fails to help cure some children with acute lymphoblastic leukemia (ALL) because molecules released by certain cells in the bone marrow counteract the effect of that drug, according to investigators at St. Jude Children's Research Hospital.

The researchers showed that mesenchymal cells in the bone marrow create a protective niche for leukemic cells by releasing large amounts of asparagine, an amino acid that nearby leukemic cells must have to survive but do not make efficiently. This extra supply of asparagine helps leukemic cells survive treatment with asparaginase, a drug that normally would deplete their supply of this vital nutrient, the researchers reported.

For parents, 8 million cases of acute middle ear infections every year add up to a lot of sleepless nights and trips to the pediatrician. But new research from a collaboration between Rockefeller University and St. Jude Children’s Hospital could change all that.

In the March 23 issue of PLoS Pathogens, Rockefeller’s Vincent A. Fischetti and colleagues at St. Jude show that middle ear infections in mice can be prevented by giving the mice a lysin – a protein derived from a virus that infects bacteria. The new technology may prevent children with the flu from developing secondary ear infections and would be an attractive alternative to traditional antibiotics, to which bacteria are rapidly becoming resistant.

A new study out of Alaska points out the impacts of climate change on marine ecosystems, and the need for increased research and stronger science based management to address future concerns.

Studies by a team of scientists at the North Pacific Universities Marine Mammal Research Consortium http://www.marinemammal.org/ revealed that a sudden ocean climate change 30 years ago changed today’s Alaska marine ecosystems, and may be a leading factor in the decline of Alaska’s endangered western stock of Steller sea lions.

The first published study on the environmental impact of manufactured nanoparticles on ordinary soil showed no negative effects, which is contrary to concerns voiced by some that the microscopic particles could be harmful to organisms.

Scientists added both dry and water-based forms of manufactured fullerenes - nanosized particles also known as buckyballs - to soil. The nanoparticles didn't change how the soil and its microorganisms functioned, said Ron Turco, a Purdue University soil and environmental microbiologist.

Why mitochondrial genes ditch their cushy haploid environs to take up residence in a large and chaotic nucleus has long stumped evolutionary biologists, but Indiana University Bloomington scientists report in this week's Science that they've uncovered an important clue in flowering plants.

"Plants that reproduce clonally or are capable of self-pollinating have transferred more genes from the mitochondrion to the nucleus," said graduate student Yaniv Brandvain, lead author of the paper.

Electrical noise, like the crackle heard on AM radio when lightning strikes nearby, is a nuisance that wreaks havoc on electronic devices. But within cells, a similar kind of biochemical "noise" is beneficial, helping cells transform from one state to another, according to a new study led by a UT Southwestern Medical Center researcher.

Dr.

Ultrasonic irradiation can break down ionic liquids into more environmentally benign compounds, say scientists.

Ionic liquids are widely regarded as a greener alternative to many commonly used solvents. But, concerns about their toxicity have raised questions about their use in large scale industrial applications, especially those that involve the creation of large amounts of waste.

Scientists of the University of Almeria, led by Gabriel Acién, are carrying out a research project on the development of new systems to eliminate carbon dioxide emissions thanks to the microalgae photosynthetic activity. This project, called CENIT CO2, is being developed by Spanish electricity company Endesa on the initiative of the Spanish Ministry of Industry.

On the pilot plant developed at the experimental station of Las Palmerillas, which depends on Spanish bank Cajamar, Almeria-based researchers try to prove the validity of this new method for eliminating CO2 emissions. It seems that in one year time, the system will be fully operative and therefore tests can be started at an industrial level.

If this were true, it would make it more difficult to promote a quality website of terrific scientists, right?

Maybe - maybe not. Perhaps it is instead the case that information democracy is replacing sources that are hampered by niche fields or ideology or politics.

I realize that the audience for this blog tends to be more broad based than on UsefulChem but once in a while I'll throw in an organic chemistry puzzle to see if there are any organic chemists out there lurking.

Ever since we isolated our Ugi products, we've been trying to cyclize them to the diketopiperazines. As described by Hulme, we are trying to effect an intramolecular transamidation catalyzed by trifluoroacetic acid (TFA).