Mitochondria provide the lion’s share of energy that cells need to function normally, so genetic defects in mitochondria can cause severe diseases that can be devastating if not caught and treated early.
Mitochondria remain important throughout our lives. People with higher mitochondria function age 'better.'
Yet how mitochondrial defects lead to disease and aging has not been well understood.
A paper published today in
Aging Cell links mitochondrial dysfunction to the shortening of telomeres, specialized DNA sequences that act as caps that stabilize the ends of chromosomes, and premature aging.