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What Next For Messenger RNA (mRNA)? Maybe Inhalable Vaccines

No one likes getting a needle but most want a vaccine. A new paper shows progress for messenger...

Toward A Single Dose Smallpox And Mpox Vaccine With No Side Effects

Attorney Robert F. Kennedy Jr. and his US followers over the last 25 years have staunchly opposed...

ChatGPT Is Cheaper In Medicine And Does Better Diagnoses Even Than Doctors Using ChatGPT

General medicine, routine visits and such, have gradually gone from M.D.s to including Osteopaths...

Even After Getting Cancer, Quitting Cigarettes Leads To Greater Longevity

Cigarettes are the top lifestyle risk factor for getting cancer, though alcohol and obesity have...

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It would be madness today to think of farmers as wimpy - watching a 160 lb. kid throw a giant hay bale around does not make people think of weakness - but skeletally the invention of agriculture made us weak compared to foraging ancestors.

As we shifted from foraging to farming, we had more food and that led to more culture and education and progress - but it also brought more sedentary lifestyles and so our skeletons have become much lighter and more fragile since the invention of agriculture.

Multiple sclerosis is a degenerative disease and most patients with RRMS who received disease-modifying therapies experience breakthrough disease. Autologous (using a patient's own cells) hematopoietic cell transplant (HCT) has been studied in multiple sclerosis with the goal of removing disease-causing immune cells and resetting the immune system.

The gene TRK was shown to cause a small percentage of colon cancers in 1982 and then in 2013 and 2014, sequencing of tumor samples found fusions of the TRK family of genes in at least 11 tumor types, including lung, breast and melanoma . 

The TRK family of genes, including NTRK1, NTRK2 and NTRK3 are important in the developing nervous system. In the womb, these genes and the proteins they encode are essential for the growth and survival of new neurons. After birth, these genes are unneeded in many tissues and so are programmed to go dormant.

Some cancers wake them up - when improperly fused with other nearby genes, genes in the TRK family can restart their ability to signal cells to grow and become immortal, which in adult tissues can cause cancer.

About 10 percent of Asia can claim to be descended from Genghis Khan and they are absolutely correct, genetic studies show; the reason is that part of the benefit to rampaging across Asia, the mid-East and into Europe was a lot of sex.

But it isn't just conquering Mongols, even on a small scale violent conflict offers biological rewards to those those who take part in it, say anthropologists who correlated violent raids and combat to reproductive fitness. 

There is no question there are genetic and environmental components to cancer but a statistical model that measures the proportion of cancer incidence across many tissue types finds that cancer is caused mainly by random mutations that occur when stem cells divide.

According to scientists from the Johns Hopkins Kimmel Cancer Center, two-thirds of adult cancer incidence across tissues can be explained primarily by "bad luck," when these random mutations occur in genes that can drive cancer growth, while the remaining third are due to environmental factors and inherited genes.

The implications of their model range from altering public perception about cancer risk factors to the funding of cancer research, they say.

The most recent outbreak of the Ebola virus disease occurring in West Africa may have originated from contact between humans and virus-infected bats, according to a new study in EMBO Molecular Medicine, which identifies insectivorous free-tailed bats as plausible reservoirs and expands the range of possible Ebola virus sources to this type of bats.

The virus that spread from Meliandou into other areas of Guinea and Sierra Leone, Liberia, Nigeria and Senegal, represents the largest ever-recorded Ebola outbreak killing 7,800 people as of December 17th 2014.