Investigators from the Ludwig Institute for Cancer Research (LICR) and the University of California, San Diego (UCSD) have made a breakthrough in identifying functional elements in the human genome, according to a report published online today in Nature Genetics.

While the DNA sequence can identify genes (the ‘what’) within the genome, it cannot answer the more fundamental questions of ‘how,’ ‘when’ and ‘where’ gene products are expressed. However, the LICR team and collaborators have developed a novel method to identify and predict the ‘promoter’ and ‘enhancer’ regions that switch on transcription, the first step in gene expression.

A Georgia Tech physics group has discovered how and why the electrical conductance of metal nanowires changes as their length varies. In a collaborative investigation performed by an experimental team and a theoretical physics team, the group discovered that measured fluctuations in the smallest nanowires’ conductance are caused by a pair of atoms, known as a dimer, shuttling back and forth between the bulk electrical leads. Determining the structural properties of nanowires is a big challenge facing the future construction of nanodevices and nanotechnology. The paper appears in the January 26th issue of Physical Review Letters.

The transition from an ice age to an ice-free planet 300 million years ago was highly unstable, marked by dips and rises in carbon dioxide, extreme swings in climate and drastic effects on tropical vegetation.

"This is the best documented record we have of what happens to the climate system during long-term global warming following an ice age," said Isabel Montañez, professor of geology at the University of California, Davis, and lead author on the paper. But she added that these findings cannot be applied directly to current global warming trends.

In the mid-Permian, 300 million years ago, the Earth was in an ice age. Miles-thick ice sheets covered much of the southern continent, and floating pack ice likely covered the northern polar ocean.

Women who become pregnant in spring are more vulnerable to preterm birth than those who conceive in other seasons, according to researchers at the University of Pittsburgh.

Also, read Scientific Blogging columnist Seth Robert's interview with Brian Wansink here.

Researchers at Canada's National Institute for Nanotechnology (NINT) are learning which molecular scale factors affect the assembly and disassembly of microtubules that are part of a cell's skeleton. Microtubules control the division of all cells with a nucleus by constantly assembling at one end while they disassemble at the other.