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TSRI Scientists Stabilize HIV Structure, Design Potential AIDS Vaccine Candidates

TSRI Scientists Stabilize HIV Structure, Design Potential AIDS Vaccine Candidates

LA JOLLA, CA - June 28, 2016 - Want to catch a criminal? Show a mugshot on the news.
Want to stop HIV infections? Get the immune system to recognize and attack the virus's tell-tale structure.
That's part of the basic approach behind efforts at The Scripps Research Institute (TSRI) to design an AIDS vaccine. This strategy may hinge on finding new ways to stabilize proteins called HIV-1 surface antigens and in designing HIV-like particles to prompt the body to fight the real virus.

A Lesson From Fruit Flies

A Lesson From Fruit Flies

Mucolipidosis IV (MLIV) is a devastating early childhood neurological disease characterized by progressive neurodegeneration, leading to severe impairments in muscle coordination, cognitive deficits and retinal degeneration that causes blindness.
There is no effective treatment for the condition, symptoms of which usually appear within a year of birth -- and whose rarity makes it a low priority for pharmaceutical companies.
But a possible first therapy has been discovered by biologist Craig Montell and his team of scientists at UC Santa Barbara. In a new study, researchers in Montell's lab found that bone marrow transplantation (BMT) significantly delayed the onset of motor deficits in an MLIV mouse model. Their findings appear in the journal Human Molecular Genetics.

Lung Cancer Experts Seek Public Comments On Revised Molecular Testing Guideline

Lung Cancer Experts Seek Public Comments On Revised Molecular Testing Guideline

BETHESDA, MD. -- June 28, 2016 -- The College of American Pathologists (CAP), the International Association for the Study of Lung Cancer (IASLC), and the Association for Molecular Pathology (AMP) announced today the open comment period for the revised evidence-based guideline, "Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors."

Lab-tested Diagnosis Needed When Treating Patients With Persistent Diarrhea

Lab-tested Diagnosis Needed When Treating Patients With Persistent Diarrhea

HOUSTON - (June 28, 2016) - Persistent diarrhea, which is diarrhea that lasts at least 14 days, is an illness typically caused by parasites or bacteria and requires accurate diagnosis in order to determine what treatment to give, according to Herbert L. DuPont, M.D., director of the Center for Infectious Diseases at The University of Texas Health Science Center at Houston (UTHealth) School of Public Health.
In a literature review published today in JAMA, the Journal of the American Medical Association, DuPont advised medical practitioners to be alert when diagnosing persistent versus acute diarrhea in patients. It is common for doctors not to focus on how many days their patients have had diarrhea, he added.

No Need In Supercomputers

No Need In Supercomputers

A group of physicists from the Skobeltsyn Institute of Nuclear Physics, the Lomonosov Moscow State University, has learned to use personal computer for calculations of complex equations of quantum mechanics, usually solved with help of supercomputers. This PC does the job much faster. An article about the results of the work has been published in the journal Computer Physics Communications.

'Squishy' Motors And Wheels Give Soft Robots A New Ride

'Squishy' Motors And Wheels Give Soft Robots A New Ride

A small, squishy vehicle equipped with soft wheels rolls over rough terrain and runs under water.
Future versions of the versatile vehicle might be suitable for search and rescue missions after disasters, deep space and planet exploration, and manipulating objects during magnetic resonance imaging (MRI), according to its creators at Rutgers University.
Their most important innovation is a soft motor that provides torque without bending or extending its housing, said Aaron D. Mazzeo, assistant professor in the Department of Mechanical and Aerospace Engineering, who coauthored the study.

High Expectations Of CERN -- Focus On Particle Physics At Lindau Nobel Laureate Meeting

High Expectations Of CERN -- Focus On Particle Physics At Lindau Nobel Laureate Meeting

The smallest building blocks of matter were the focus of a panel discussion held yesterday at the 66th Lindau Nobel Laureate Meeting.
In particular, laureates Steven Chu, David J. Gross, Takaaki Kajita and Carlo Rubia together with three young scientists working at the European nuclear research centre CERN in Geneva spoke about recent experiments designed to detect hitherto unknown particles. The Director General of CERN, Fabiola Gianotti, was also present via live video stream.

New Electric Mesh Device Gives The Heart An Electromechanical Hug

New Electric Mesh Device Gives The Heart An Electromechanical Hug

BOSTON - A research team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) and Seoul National University has developed a new electric mesh device that can be wrapped around the heart to deliver electrical impulses and thereby improve cardiac function in experimental models of heart failure, a major public health concern and leading cause of mortality and disability.
The study, published in the June 22, 2016 issue of Science Translational Medicine, points to a potential new way of improving heart function and treating dangerous arrhythmias by compensating for damaged cardiac muscle and enabling living heart muscle to work more efficiently.

New Model Predicts Once-mysterious Chemical Reactions

New Model Predicts Once-mysterious Chemical Reactions

LOS ALAMOS, N.M., June 28, 2016--A team of researchers from Los Alamos National Laboratory and Curtin University in Australia developed a theoretical model to forecast the fundamental chemical reactions involving molecular hydrogen (H2), which after many decades and attempts by scientists had remained largely unpredicted and unsolved.
"Chemical reactions are the basis of life so predicting what happens during these reactions is of great importance to science and has major implications in innovation, industry and medicine," said Mark Zammit, a post-doctorate fellow in the Physics and Chemistry of Materials group at Los Alamos National Laboratory. "Our model is the first to very accurately calculate the probability of fundamental electron-molecular hydrogen reactions."

Doing The Math On Zika And Sex

Doing The Math On Zika And Sex

A University of Miami math professor has developed a scientific model to address the various ways the Zika virus proliferates. The study, published June 17, 2016 in Scientific Reports, reveals that mosquito control should remain the most important mitigation method to control the virus. However, the study reveals that Zika is a complicated virus and sexual transmission increases the risk of infection and prolongs the outbreak.
CORAL GABLES, Fla. (June 28, 2016) - Before British long jumper Greg Rutherford departs for the Olympic Games in Rio de Janeiro this summer, he'll leave an important part of himself behind: a sample of his frozen sperm.

Tampon Makers Could Help Reduce Violence Against Women

Tampon Makers Could Help Reduce Violence Against Women

Manufacturers of feminine hygiene products, including tampons and sanitary products, could dedicate a part of their revenues to support public health programmes that prevent violence against women, argues an expert in The BMJ this week.
Physical and sexual violence is a public health problem that affects more than one third of all women, equivalent to at least a billion women globally, according to a World Health Organization (WHO) study.
Effective programmes and strategies to prevent domestic and sexual violence, the two most common types, have been identified by the WHO and collaborators, but these are "hugely underfunded", argues Dr S D Shanti, associate professor of public health from the A T Still University of Health Sciences, USA.

Night-time Light Pollution Causes Spring To Come Early

Night-time Light Pollution Causes Spring To Come Early

Human use of artificial light is causing Spring to come at least a week early in the UK, researchers at the University of Exeter in Cornwall have found.
New research led by a team of biologists based at the University's Penryn campus highlights for the first time and at a national scale the relationship between the amount of artificial night-time light and the date of budburst in woodland trees.