Research led by Dr. Keiji Tanimoto from the University of Tsukuba, Japan, has brought us closer to understanding the mechanisms underlying the phenomenon of genomic imprinting. In this intriguing event, one copy of a gene is 'turned off', or silenced, depending on whether it was derived from the mother or the father. The research team has identified a segment of DNA that is essential in the imprinting process for the closely linked Igf2/H19 genes, two of the first imprinted genes to be discovered. If these genes are incorrectly imprinted, it can lead to the overgrowth (Beckwith-Wiedemann) or dwarfism (Silver Russell) syndromes, and also has a role in some kidney and liver cancers.