The drug trastuzumab (Herceptin) is used to treat HER2-positive breast cancer (a type of breast cancer that overexpresses the HER2 gene and accounts for about 25% of all breast cancers). Trastuzumab therapy improves the chances of survival; however, it has deleterious side effects and is expensive. Thus, it is important to accurately determine the patient’s HER2 status.

The challenge is to develop a testing strategy that is both accurate and economical. A false-negative test result can mean a woman will not receive a life-prolonging drug, and a false-positive result can lead to unnecessary, expensive drug treatment.

Pacific Northwest National Laboratory geologists have put out a call for teeth tusks, femurs and any and all other parts of extinct mammoths left by massive Ice Age floods in southeastern Washington.

New evidence on sex differences in people’s brains and behaviors emerges with the publication of results from the British Broadcasting Corporation’s (BBC) Sex ID Internet Survey. Survey questions and tests focused on participants’ sex-linked cognitive abilities, personality traits, interests, sexual attitudes and behavior, as well as physical traits. The Archives of Sexual Behavior¹ has devoted a special section in its April 2007 issue to research papers based on the BBC data.

Diabetes researchers, investigating how the body supplies itself with insulin, discovered to their surprise that adult stem cells, which they expected to play a crucial role in the process, were nowhere to be found. Many researchers had proposed that adult stem cells develop into insulin-producing cells, called beta cells, in the pancreas.

Instead, the beta cells themselves divide, although slowly, to replenish their own population.

Researchers at the University of Illinois have developed a simple and economical technique for imaging and mapping fruit fly chromosomes. This new approach will enable them to construct the first accurate map of the chromosomes and tease out the secrets hidden in their stripes.

Don't feel bad if you want to be part of the "in" crowd. It may be hardwired in our brain cells.

Even newborn brain cells reach out to mature brain cells that are already well connected within the established circuitry, report scientists at the Salk Institute for Biological Studies in the online edition of Nature Neuroscience.