Addressing a current issue in neuroscience, Aldo Faisal and Simon Laughlin from Cambridge University investigate the reliability of thin axons for transmitting information. They show that noise effects in ion channels in the brain are much larger than previously assumed – meaning the fidelity of transmission is compromised.

Cellular survival relies crucially on the ability to receive and communicate signals from and to the outside world. A major part of this regulation and communication is performed by proteins within the membrane of a cell. How these proteins work is an important topic in biology, and one which these scientists have excellently clarified by computational techniques.

Tristan Ursell and colleagues have examined the elasticity of the membrane, which changes thickness to accommodate the proteins embedded within it. Proteins respond to stimuli by altering their shape to perform specific tasks, such as channel proteins, which allow the flow of ions in only one formation.

Regular as clockwork, the flu arrives every year. And, according to the national Centers for Disease Control and Prevention, 5 to 20 percent of the U.S. population on average will come down with it. About 36,000 people will die.

But among health experts, a bigger concern than the seasonal flu is an outright flu pandemic, such as a human strain of avian flu. And officials say it is not a question of if such a health crisis will come but when. Are we prepared? In a word, say three UCLA researchers, no.

The identification of a cluster of essential genes on mouse chromosome 11 as well as similar clusters on the chromosomes of other organisms – including humans – buttresses the argument that there may be rules as to how genes are structured or laid out on chromosomes, said the Baylor College of Medicine senior author of a report that appears online today in the Public Library of Science Genetics, an open-access publication.

Adults with recurrent sore throats may benefit from having a tonsillectomy in the short term, but the overall longer term benefit is still unclear, and any benefits have to be balanced against the side effects of the operation, according to this week's BMJ.

A small study of adults from Finland, published on bmj.com last month, showed that tonsillectomy significantly reduced the likelihood of further infection after 90 days, compared with watchful waiting.

With funding provided by the Wisconsin Partnership Fund for Health and the American Academy of Family Physicians Foundation, Jennifer Eddy of UW Health's Eau Claire Family Medicine Clinic is currently conducting the first randomized, double-blind controlled trial of honey for diabetic ulcers. Eddy first successfully used honey therapy a few years ago with a patient who was facing amputation after all medical options had been exhausted.