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A drug under study to treat various cancers selectively kills cancer cells because of its affinity for a modified version of a critical heat shock protein they contain, researchers have found.

They found in cancer a modified version of heat shock protein 90, or hsp90, which like most heat shock proteins, promotes cell survival.

Research by Renee Theiss, Jason Kuo and C J Heckman, which has just been published in The Journal of Physiology, throws light on how information is processed in the Central Nervous System (CNS) to drive movement. The findings are relevant to understanding mechanisms underlying movement and disorders such as spinal cord injury and motor neurone disease (ALS).

The controversial idea that one cause of high blood pressure lies within the brain, and not the heart or blood vessels, has been put forward by scientists at the University of Bristol, UK, and is published this week in the journal Hypertension.

Dr. Hidefumi Waki, working in a research group led by Professor Julian Paton, has found a novel role for the protein, JAM-1 (junctional adhesion molecule-1), which is located in the walls of blood vessels in the brain.

Researchers have successfully applied X-ray scattering techniques to determine how dissolved metal ions interact in solution.

These findings will help researchers better understand how metal ions, such as those found in nuclear waste and other industrial processes, behave in the environment.


Researchers at the Department of Energy's Argonne National Laboratory and the University of Notre Dame have successfully applied X-ray scattering techniques to determine how dissolved metal ions interact in solution. Credit: Argonne National Laboratory

A new theoretical thermometer built from heavy-duty mathematics and computer code suggests that the surfaces of certain neutron stars run significantly hotter than previously expected. Hot enough, in fact, to at least partially answer an open question in astrophysics -- how to explain the observed frequency of ultra-violent explosions known as superbursts that sometimes ignite on such stars' surfaces?


Neutron star accreting matter from a red giant star. The red giant (on the upper right) is expanding and dumping material onto the neutron star. This material forms a disk and then finally falls to the neutron star surface. Credit: Tony Piro, U.C. Berkeley

Human bone marrow has been used to create early-stage sperm cells for the first time, a scientific step forward that will help researchers understand more about how sperm cells are created.

The research published in the academic journal Reproduction: Gamete Biology, was carried out in Germany* by a team of scientists led by Professor Karim Nayernia, formerly of the University of Göttingen but now of the North-east England Stem Cell Institute (NESCI), based at the Centre for Life in Newcastle upon Tyne.


How Prof Nayernia and his team cultured from human bone marrow. Credit: Newcastle University, England