Pharmacology

Dietary capsaicin, the active ingredient in chili peppers, produces chronic activation of a receptor on cells lining the intestines of mice, triggering a reaction that ultimately reduces the risk of…

Resistance to artemisinin, the main drug to treat malaria, has become widespread throughout Southeast Asia. Resistance among the Plasmodium falciparum (P. falciparum) parasites that cause the disease…

The pesticide methoxychlor has been linked to adult onset kidney disease, ovarian disease and obesity - generations after rats were exposed.   Methoxychlor, also known as Chemform, Methoxo,…

For two decades, women at risk of developing placental blood clots have been prescribed the anticoagulant low molecular weight heparin (LMWH) but it's ineffective, according to a clinical trial…

Pharmaceutical companies are in a tough position; they are highly regulated, trials are expensive, new products fail most of the time, and if they are successful, everyone complains the cost is too…

Ketamine has been used by emergency departments for analgesia, sedation and amnesia for rapid, life-saving intubation in critically ill patients but decades-old studies suggested it raised…

A multicenter team of researchers report that in a phase III clinical trial, a combination drug therapy cures chronic hepatitis C in the majority of patients co-infected with both HIV and hepatitis C…

Niacin has been a mainstay cholesterol therapy for 50 years but it should no longer be prescribed for most patients due to potential increased risk of death, dangerous side effects and no benefit in…

Researchers have created a combination drug that controls both tumor growth and metastasis. By combining a COX-2 inhibitor, similar to Celebrex, and an epoxide hydrolase (sEH) inhibitor, the drug…

Mice exposed to arsenic in drinking water developed lung cancer in a new study by researchers at the National Institutes of Health have found.  In the study, researchers gave mice orders of…