The past is difficult to recover because it was built on the foundation of its own history, one irrevocably different from that of the present and its many possible futures.
From "An epistatic ratchet constrains the direction of glucocorticoid receptor evolution", Jamie T. Bridgham, Eric A. Ortlund&Joseph W. Thornton.
Thanks to the Redneck Geneticist for finding this paper and not emailing me about it.
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