A century-old dream of neuroscientists to visualize a memory has been fulfilled, as University of California, Irvine researchers, using newly developing microscopic techniques, have captured first-time images of the changes in brain cell connections following a common form of learning.
The study shows that synaptic connections in a region of rats’ brains critical to learning change shape when the rodents learn to navigate a new, complex environment. In turn, when drugs are administered that block these changes, the rats don’t learn, confirming the essential role the shape change plays in the production of stable memory.
“This is the first time anyone has seen the physical substrate, the ‘face,’ of newly encoded memory.