Dr. Ronald Evans (Salk Institute) and colleagues have discovered that mutations in the mouse gene encoding PPARγ adversely affect lactation milk quality, and have serious health consequences for nursing pups.
“By examining PPARγ functions in vivo, our work reveals an unexpected link between diet, inflammation and the quality of mothers milk, “ explained Dr. Evans.
PPARγ (peroxisome proliferator-activator receptor gamma) is a nuclear receptor that is known to regulate metabolism and inflammation in various organisms. In fact, human PPARγ is the main target of the drug class of thiazolidinediones (TZDs), which is used to manage diabetes.