Topotecan, a cancer inhibitor, interacts with an important protein (TopoIB), causing a (cancer) cell to malfunction. The TopoIB protein is responsible for the removal of loops from DNA, which arise amongst other things during cell division.

The TopoIB protein binds to the DNA molecule, clamps around it and cuts one of the two DNA strands, after which it allows it to unwind and finally joins the broken ends together.

Until now it has been supposed that topotecan only causes the TopoIB protein to reside longer than normal on the DNA molecule, disturbing the cell division and damaging the (cancer) cell. But the researchers at the University of Delft have now discovered that adding topotecan also dramatically impedes the unwinding and that DNA loops accumulate as a result.

Dental enamel is the thin, outer layer of hard tissue that helps maintain the tooth's structure and shape while protecting it from decay.

While eating fruit is important part of a balanced diet, how you eat it may be ruining your teeth, says David Bartlett, BDS, PhD. Frequently consuming foods with a low pH (potential of hydrogen) value, such as fresh fruit, pickles, yogurt, honey, fruit juices and raisins can lead to irreversible dental erosion.

Eventually, because of repeated exposure to acid, the tooth’s enamel will lose its shape and color and as the damage progresses; the underlying dentin, (which is the tissue that makes up the core of each tooth), becomes exposed causing the teeth to look yellow.

New Test Determines if Osteoporosis Treatment Drug May Cause Jawbone to Die.

Breast cancer patients, individuals at risk for osteoporosis, and individuals undergoing certain types of bone cancer therapies often take drugs that contain bisphosphonates. Bisphosphonates may place patients at risk for developing osteonecrosis of the jaws, which is irreversible damage in which the jaw bone rots away.

The future of biolectronics - being able to diagnose diseases, detect poisons and monitor health instantly - may still seem far away, but it may be closer than you think.

Researchers understand what biochemical reactors they need to monitor and they know which microelectronics they would need to use. They have just been unable to combine them because measuring the ions in receptors within cell membranes destroyed the cells being measured.

A team at the Max Planck Institute say they have solved the problem and describe the coupling of a receptor to a silicon chip by means of a cell–transistor interface. True bioelectronics at its most basic level.

Physicians have recognized scoliosis, the abnormal curvature of the spine, since the time of Hippocrates, but its causes have remained a mystery -- until now. For the first time, researchers have discovered a gene that underlies the condition, which affects about 3 percent of all children.

The new finding lays the groundwork for determining how a defect in the gene -- known as CHD7 -- leads to the C- and S-shaped curves that characterize scoliosis.

"Hopefully, we can now begin to understand the steps by which the gene affects spinal development," says Anne Bowcock, Ph.D., professor of genetics, of medicine and of pediatrics at Washington University in St. Louis.

There aren't many people who will claim that the government is here to help you and they will save you money, but Chris Cooper and Benjamin Sovacool are doing just that. Cooper is Senior Policy Director, Network for New Energy Choices while Sovacool is a Senior Research Fellow and teaches in the Government and International Affairs program at Virginia Tech.

They recently completed a study advocating a national energy policy mandating renewable energy.

Giant prehistoric penguins? In Peru? It sounds more like something out of Hollywood than science, but a researcher from North Carolina State University along with U.S., Peruvian and Argentine collaborators has shown that two heretofore undiscovered penguin species reached equatorial regions tens of millions of years earlier than expected and during a period when the earth was much warmer than it is now.

Paleontologist Dr. Julia Clarke, assistant professor of marine, earth and atmospheric sciences at NC State, and colleagues studied two newly discovered extinct species of penguins. Peruvian paleontologists discovered the new penguins’ sites in 2005.

Recent studies showing that commonly used anesthetic agents can cause brain damage in animals don't prove that similar harmful effects occur in human newborns—and shouldn't affect current approaches to anesthesia in preterm and ill infants, according to a leading expert on pain management in newborns.

The July issue of the journal Anesthesiology features an editorial by Dr. Kanwaljeet J.S. Anand, Professor of Pediatrics, Anesthesiology, Pharmacology, Neurobiology & Developmental Sciences in the College of Medicine, University of Arkansas for Medical Sciences and Director of the Pain Neurobiology Lab at Arkansas Children’s Hospital Research Institute.

Folk medicine, prayer, astrology, spells, mysticism - your treatment for disease in medieval times mattered most on the beliefs of the people around you rather than a codified study of the body.

It was commonly believed that body health resulted from a balance of the 'humours' in the body - black bile, phlegm and blood and yellow bile- and that a lack of balance meant an issue with a particular organ. Even today those beliefs are prevalent in the use of terms that described them then - if you have ever heard someone described as 'melancholic', it refers to an issue with their spleen resulting in too much black bile.

Many of the practices used then are still in use today.

18-year old Nicholas Tan Xue-Wei will soon depart for the U.S. to present a research paper at The 2007 World Congress in Computer Science, Computer Engineering, and Applied Computing (WORLDCOMP'07), June 25 to 28, in Las Vegas.

Before returning home to Singapore, Nicholas will continue to represent Singapore's Bioinformatics Institute by presenting his research paper at the World Congress on Engineering 2007 (WCE 2007), July 2 to 4 in London.

Nicholas will speak about his research paper, titled “Towards A Serum-Free Medium: Growth Receptors And Signaling Pathways That Regulate Multipotency In Human Mesenchymal Stem Cells."