Acrux announced positive results from its Phase 1 clinical studies
using two unique contraceptive skin sprays, each containing a progestin and an estrogen.
The first study was a Phase I, pharmacokinetic study, investigating the delivery of a formulation combining Nestorone® and the synthetic estrogen, Ethinyl Estradiol. A single dose of the combination formulation was applied to the forearm of healthy volunteers.
The results showed that the dosing of the contraceptive spray provided effective delivery of both contraceptive agents, with blood concentrations of Nestorone® and Ethinyl Estradiol in the target range expected to provide effective contraception.
The spray was well tolerated, with no serious adverse events recorded.