Investigators from the Ludwig Institute for Cancer Research (LICR) and the University of California, San Diego (UCSD) have made a breakthrough in identifying functional elements in the human genome, according to a report published online today in Nature Genetics.
While the DNA sequence can identify genes (the ‘what’) within the genome, it cannot answer the more fundamental questions of ‘how,’ ‘when’ and ‘where’ gene products are expressed. However, the LICR team and collaborators have developed a novel method to identify and predict the ‘promoter’ and ‘enhancer’ regions that switch on transcription, the first step in gene expression.