17 genomes of supercentenarians, people living beyond 110 years of age, haven't led us any closer to discovering protein-altering variants significantly associated with extreme longevity, according to a study in PLOS ONE by Hinco Gierman from Stanford University and colleagues.

There are 74 supercentenarians alive worldwide, with 22 in the United States. The authors of this study performed whole-genome sequencing on 17 of them to explore the genetic basis underlying extreme human longevity. 

It was a small sample size but even if it were large it may not make a difference.  The researchers were unable to find rare protein-altering variants significantly associated with extreme longevity compared to control genomes, perhaps because it does not exist.  Supercentenarians have diverse lifestyles, everything from smoking history to high red meat and fat consumption, and little in common biologically that could be considered a 'fountain of youth'.

They did find that one supercentenarian carries a variant associated with a heart condition, which had little or no effect on his/her health, since they were already over 110 years old.

The authors added that it is recommended by the American College of Medical Genetics and Genomics to report the results to this individual as an incidental finding. Although the authors didn't find significant association with extreme longevity, the authors have publicly published the genomes, making them available as a resource for future studies on the genetic basis of extreme longevity.