In civilized war, as oxymoronic as it sounds, hospitals have a cultural bubble around them, neutral territory and off limits. 

But in Syria, that bubble has burst dozens of times, according to a new report from the group Physicians for Human Rights. The hospitals in just the eastern half of Aleppo city have suffered 45 attacks in three years, and two-thirds have closed.

And that may put medical facilities and workers in other conflict zones in danger too, according to a new opinion piece in the New England Journal of Medicine

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A map of the area of Syria around Aleppo, highlighting the group in control of each area of territory. Credit: The Carter Center/Palantir Technologies/Physicians for Human Rights

They call on the international community to react to these violations of international humanitarian law, and of the principle of medical neutrality.

"Medical professionals around the world think of Syria as not affecting them, but the situation there is setting a terrifying precedent throughout the world," says Michele Heisler, M.D., MPA, of the University of Michigan. "For much of the 20th century, warring parties for the most part had respected medical neutrality and allowed doctors and nurses to provide health care in conflic - but once that starts to be eroded it could make even the basic provision of health care impossible."

Heisler and her colleagues documented the plight of Aleppo hospitals by interviewing 25 Syrian physicians and other health care workers. Many had crossed the border into Turkey to attend a medical conference held this past July by the Syrian American Medical Society. They returned to their posts afterward, despite knowing that over 95 percent of Aleppo's doctors have fled the country, or been detained or killed.

The report examines the impact of attacks on the medical infrastructure and personnel in the portion of Aleppo held by opposition forces and the healthcare status and needs of the civilians in eastern Aleppo.

In the NEJM piece, Heisler and her colleagues recount some of the report's major findings and the history of the Geneva Conventions dating back to 1864 that have protected hospitals and medical teams in wartime. They describe the particular effects of the barrel bombs dropped on hospitals and other civilian spaces, and the strategies that Aleppo's health professionals use to treat those wounded by these bombs and provide medical care despite shortages of human and material resources.

Filled with explosives, shrapnel, nails, and oil and weighing 200 to 2000 pounds, barrel bombs are dropped from helicopters and break into thousands of fragments upon impact. The numerous wounds they cause require trauma care, and the remaining hospitals and teams struggle to provide needed treatment. No working MRI or CT scanners remain in Aleppo.

Because of this targeting, hospitals have literally had to move underground. When possible, as many operations as possible have been moved into basements. Most hospitals still functioning in Aleppo have been attacked repeatedly. One has been hit seven times.