In a world where "antibiotic resistance" has been a concern, not just among those opposed to medical science but by mainstream consensus, it may seem odd to discuss the benefits of preventative antibiotics, but a large randomized trial indicates that the World Health Organisation and other national organizations should change antibiotic guidelines, at least for assisted childbirth.In 2016, an estimated 19,500 women died because of pregnancy-related infections globally. Even in high-income settings, infections account for 1 in 20 maternal deaths, and as many as 1 in 8 in the USA. For every woman who dies from pregnancy-related infection, another 70 women develop a severe infection and survive often with long-term health consequences.