Why Both Stimulating And Blocking GLP-1R Helps People Lose Weight
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
Scientists from the Institute of Biochemistry and Molecular Biology and Collaborative Research Center 746 of the University of Freiburg say they have discovered a new mechanism which plays an essential role in the assembly and growth of mitochondria, the 'power plants' of the cell.These organelles make energy stored in food ready for use by the cell. The generators in the cellular power plants are biological membranes located inside the mitochondria. Even minute errors in the composition of the inner mitochondrial membrane can lead to severe metabolic derangements, which can have an especially negative impact on the energy-hungry muscle and nerve cells.
During pregnancy, many women experience remission of autoimmune diseases like multiple sclerosis and uveitis and scientists have described a biological mechanism they say is responsible for changes in the immune system that helps explain that remission.The expression of an enzyme known as pyruvate kinase is reduced in immune cells in pregnant women compared to non-pregnant women, says biophysicist Howard R. Petty from the University of Michigan Kellogg Eye Center, and Roberto Romero, M.D., of the National Institutes for Health. Their study coming in the August issue of the American Journal of Reproductive Immunology also reports that expression of the enzyme is lower in pregnant women compared to those with pre-eclampsia, a condition with inflammatory components.
Astronomers have glimpsed what could be the youngest known star at the very moment it is being born -so young it can hardly be considered a true star because it is in the earliest stages of star formation and has just begun pulling in matter from a surrounding envelope of gas and dust.The Astrophysical Journal study authors found the object using the Submillimeter Array in Hawaii and the Spitzer Space Telescope. The new star, known as L1448-IRS2E, is located in the Perseus star-forming region about 800 light years away yet within our Milky Way galaxy.
Lithium has been used for more than 50 years in the treatment manic depression, clinically termed bipolar disorder, though no one is sure why it has been beneficial.Don't be concerned. We don't know why aspirin works either, but we still use it.Still, science mysteries are going to be pursued and new research from Cardiff University suggests a possible mechanism for why Lithium works, opening the door for better understanding of the illness and potentially more effective treatments.
If we can't get rid of CO2, the greenhouse gas that gets the most press, perhaps we can store it, say researchers. Maybe even in rock form. Carbon dioxide when mixed with water forms carbonic acid (also known as carbonated water or soda water), which can percolate through rocks, dissolving some minerals and forming solid carbonates with them, thereby storing the carbon dioxide in rock form.Sigurdur Gislason of the University of Iceland has been studying the possibility of sequestration of carbon dioxide (CO2) in basalt and presented his findings today to several thousand geochemists from around the world at the Goldschmidt Conference hosted by the University of Tennessee, Knoxville, and Oak Ridge National Laboratory.
Some estimates claim that within the first week after giving birth, up to 70 percent of women experience symptoms of the 'baby blues' - obviously a different thing than clinical postpartum depression, which perhaps 13 percent of new mothers show symptoms of having and is defined as a major depressive episode starting within 4 weeks after delivery.Milder postpartum blues are obviously a major risk factor for developing postpartum depression and severe postpartum blues symptoms can be viewed as a prodromal stage for postpartum depression, say researchers, and in a new paper they reveal an increase of the enzyme MAO-A throughout the female brain in the immediate postpartum period and propose a neurobiological model for postpartum blues.
Hydrogen is the fuel-cell future but currently it has a number of issues, primarily related to storage(1) and cost. Cost because getting hydrogen out of a molecule requires a catalyst and efficient catalysts, like platinum, dissolve during the stop-and-go driving of a fuel-cell-powered electric car - as much as 45 percent of the catalyst can be lost during five days. You know when gold looks cheap by comparison your energy technology is not ready for the mass market.
Light beams travel in straight lines and don't go around corners, they instead spread through a process known as diffraction.Researchers at Tel Aviv University have discovered that small beams of light can indeed be bent in a laboratory setting, diffracting much less than a "regular" beam. These rays are called "Airy beams" after English astronomer Sir George Biddell Airy, who studied the parabolic trajectories of light in rainbows.
Babies can grasp information about numbers, space and time before they can speak, and they do so in more complex ways than previously realized, according to new research.In 1890 William James wrote in "The Principles of Psychology" that the baby's impression of the world as "one great blooming, buzzing confusion." But modern evidence indicates otherwise.Babies understand quantity quite well, say Emory University psychologist Stella Lourenco and University College London neuroscientist Matthew Longo, and so much earlier than thought.
There are two aspects to food research; an industry one, where food additives that can make food taste more or less sweet without calories have benefits, and a therapeutic one, like treating patients who over eat.
Lutetia is a large, primitive asteroid left on the shelf for billions of years, presumably because no planet consumed it as the Solar System formed. Most measurements affirm this, making the asteroid out to be a 'C-type', which contains primitive compounds of carbon, but some others suggest that Lutetia is an 'M-type', which could mean there are metals in its surface. If the second is true, it could be a real find in space science because although metallic asteroids do exist, they are thought to be fragments of the metallic core of larger asteroids that have since been shattered into pieces. If Lutetia is made of metal or even contains large amounts of metal, the traditional asteroid classification scheme may need rethinking.
In vitro fertilization (IVF) resulted in the first 'test tube baby' in 1978 and now an estimated 1% of all American babies born each year has happened thanks to in vitro fertilization - wonderful for parents with reproductive issues but IVF and other assisted fertility treatments may be creating one problem by solving another, according to new research from Tel Aviv University.