Why Both Stimulating And Blocking GLP-1R Helps People Lose Weight
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
A new wide-field image released today by ESO has captured a large group of galaxies belonging to the massive cluster known as Abell 315. As crowded as it may appear, this assembly of galaxies is only the proverbial "tip of the iceberg", as Abell 315 — like most galaxy clusters — is dominated by dark matter. The huge mass of this cluster deflects light from background galaxies, distorting their observed shapes slightly.
Neuroscientists from the University of Southampton investigating alcohol dependency and withdrawal in C. elegans worms say they exhibit alcohol-dependent behaviors similar to humans, despite their evolutionary distance, and very simple brain consisting of just 302 nerve cells.The research, published in PLoS One, shows that withdrawal symptoms could be relieved by small doses of alcohol. However, easing the effects can increase dependency.In humans, the symptoms are manifested in anxiety, agitation and, in extreme cases, seizures. The worms, as video footage shows, also became overactive in alcohol withdrawal and showed spontaneous and deep body bends – a behavior rarely seen in 'teetotal' worms.
The case for so-called organic farming has always been pretty weak, and a new study in Ecology Letters isn't helping the cause. The study found that the environmental benefits generated organic farming don't compensate for the lower yields produced. Increases in biodiversity from organic farming were found to be much lower than previously thought – averaging just over 12 percent more than conventional farming. Organic farms in the study also produced less than half of the yield of their conventional counterparts.
As concern grows after the explosion of the Deepwater Horizon drilling rig in the Gulf of Mexico two weeks ago, scientists are monitoring the situation closely with ESA's Envisat radar data.The spill still appears relatively confined around its point of origin and is still north of the Loop Current, a powerful conveyor belt that circulates clockwise around the Gulf toward Florida before being joining the powerful Gulf Stream.Some researchers have expressed concerned that the Loop Current could soon catch the oil slick and drag it south towards coral reefs in the Florida Keys.
Researchers writing in Nature say they can have discovered how living cells use a limited number of genes to generate enormously complex organs such as the brain.The team describes how a hidden code within DNA explains how a limited number of human genes can produce a vastly greater number of genetic messages. The discovery bridges a decade-old gap between our understanding of the genome and the activity of complex processes within cells, and could one day help predict or prevent diseases such as cancers and neurodegenerative disorders.The researchers developed a new computer-assisted biological analysis method that finds 'codewords' hidden within the genome that constitute what is referred to as a 'splicing code'.
Children who pick up smoking may not recognize the symptoms of nicotine dependence early on in the habit, say researchers writing in Pediatrics. Their study found that sixth-graders who started smoking in the 4-year period 2002–2006 were unable to recognize that symptoms such as irritability and desire to smoke are harbingers of addiction.Researchers surveyed 1246 adolescent smokers every three to four months, over the four-year period. Study participants were monitored for 10 symptoms of dependence with the Hooked on Nicotine Checklist. The association between number of symptoms and smoking frequency was examined using cross-lagged analyses.
A variant of the alcohol dehydrogenase enzyme ADH1B*3 is associated with reduced rates of alcohol dependence (AD), according to a study in Alcoholism: Clinical&Experimental Research. The enzyme variant appears to cause sedation and reduce the amount alcohol a person will drink. ADH1B*3 is found almost exclusively in populations with African ancestry, the study's authors say.
Problem gamblers react more intensely to "near misses" than casual gamblers, possibly spurring them on to play more, according to new research published in The Journal of Neuroscience. Researchers found that the brain region that responds to rewards by delivering a dose of the chemical dopamine was especially active in these individuals.Studies have shown that pathological gambling is an addiction, similar in many ways to drug addiction. The new study suggests that the degree to which a person's brain responds to near misses may indicate the severity of addiction.
A new study published in PLoS Medicine has found that skepticism about the benefit of the HPV vaccine remains high among parents of adolescent girls. Even when financial and healthcare barriers are removed, some parents remain hesitant to have their daughters receive the vaccine - the more educated parents are, the less likely it is they will consent, says the new study. As a result, policymakers must spend more money to ensure that the debate is properly framed. The authors surveyed parents of sixth-grade girls (age 11) in a publicly funded school-based program in British Columbia, Canada, to determine the level of uptake of the first dose of the HPV vaccine, and to examine the factors involved in their decision to allow receipt of the vaccine.
Pregnant mothers who smoke during pregnancy may be putting their children at risk psychiatric problems in childhood and young adulthood, according to a new study.Finnish researchers found that adolescents who had been exposed to prenatal smoking were at increased risk for use of all psychiatric drugs especially those uses to treat depression, attention-deficit/hyperactivity disorder (ADHD) and addiction compared to non-exposed youths. The study will be presented tomorrow at the Pediatric Academic Societies (PAS) annual meeting in Vancouver, British Columbia, Canada.
Researchers from the Seattle Children's Research Institute have found that teenagers who sleep less are more likely to gain weight. Their study, they say, is one of the first studies to document an association between sleep duration and weight in adolescents, even after controlling for calorie intake, activity level and depressive symptoms."Sleep has long been recognized as an important health behavior," said lead author Leslie A. Lytle. "We are just beginning to recognize its relationship to overweight and obesity in children and adults alike."
A University of Florida engineer has crafted a nickel-sized imaging device that uses organic light-emitting diode technology similar to that found in laptop screens for night vision. The device is paper-thin, light and inexpensive, making it a possible add-on for cell phones. Other applications could include night vision technology for car windshields, or even for standard glasses to use at night. A paper detailing the infrared-to-vision device was published in a recent issue of Advanced Materials.