People with cystic fibrosis suffer repeated lung infections because their airway mucus is too thick and sticky to keep bacteria, viruses, and other pathogens from causing chronic infection. How mucus becomes abnormal in
cystic fibrosis
airways has never been fully understood, but a new study has determined that mucin proteins, which give mucus its gel-like properties, fail to unfold normally in
cystic fibrosis
airways, making airway mucus much more thick and sticky than it would be otherwise.Cystic fibrosis is a rare genetic disease that affects about 70,000 people worldwide. It occurs when a person has two defective copies of the CFTR gene, which triggers the creation of the CFTR protein. When that protein is mutated, the result is cystic fibrosis.