News Articles

Scientists at the University of Bonn, together with colleagues from Romania, have discovered a gene variant that significantly increases the risk of developing gallstones.
It is estimated that one in ten Europeans has this variant in their hereditary disposition. For those affected, the likelihood of developing a gallstone in the course of their life is two to three times higher. The relevant gene contains the instructions for building a molecular pump which transports cholesterol from the liver into the bile ducts – cholesterol being the substance from which most gallstones are formed.
The genetic modification appears to cause this pump to work permanently at high speed.

A detailed understanding of key chemical reactions that take place in interstellar space has been provided by groundbreaking research at two U.S. Department of Energy national laboratories and two European universities.
Argonne National Laboratory senior chemist Stephen Klippenstein – along with colleagues at Sandia National Laboratories; the Institute of Physics, University of Rennes, France; and the University of Cambridge, U.K. – has developed a detailed understanding of the dynamics of reactions between neutral radicals and neutral molecules, known as “neutral-neutral” reactions, at temperatures as low as 20 Kelvin, approximately the temperature of interstellar space.

To protect us from disease our immune system employs macrophages, cells that roam our body in search of disease-causing bacteria. With the help of long tentacle-like protrusions, macrophages can catch suspicious particles, pull them towards their cell bodies, internalise and destroy them.
Using a special microscopy technique, researchers from the European Molecular Biology Laboratory (EMBL) now for the first time tracked the dynamic behaviour of these tentacles in three dimensions. In the current online issue of PNAS they describe a molecular mechanism that likely underlies the tentacle movement and that could influence the design of new nanotechnologies.

A research team at the Swedish medical university Karolinska Institutet has shown for the time that microRNA, small RNA molecules, may play an important role in the development of inflammatory skin diseases such as psoriasis and atopic eczema. The research team is led by Professor Mona Ståhle, one of Sweden’s most prominent scientists in the field.
MicroRNA are small RNA molecules that regulate gene expression, and by acting on many different proteins and different cellular mechanisms in skin and immune cells these small RNA molecules may be an important factor in the development of disease. Therapies based on microRNA might therefore in the future become more effective than medicines targeted at individual proteins.

Researchers from Boston University School of Medicine (BUSM) and Boston University School of Public Health (BUSPH) have developed a method to estimate sickle cell disease severity and predict the risk of death in people with this disease.
Sickle cell disease is caused by mutations in the beta-hemoglobin gene (HBB). Individuals having identical pairs of genes for the HBB glu6val mutation (HbS) have sickle cell anemia; individuals with both HbS and HbC mutations have sickle cell-HbC (HbSC) disease. Both of these types of sickle cell-disease have extremely variable characteristics. While the median age of death in the United States was estimated to be in the fifth decade for patients with sickle cell anemia, some individuals die young while others live into their eight or ninth decade.

A research team at the Swedish medical university Karolinska Institutet has shown for the time that microRNA, small RNA molecules, may play an important role in the development of inflammatory skin diseases such as psoriasis and atopic eczema. The research team is led by Professor Mona Ståhle, one of Sweden’s most prominent scientists in the field.
MicroRNA are small RNA molecules that regulate gene expression, and by acting on many different proteins and different cellular mechanisms in skin and immune cells these small RNA molecules may be an important factor in the development of disease. Therapies based on microRNA might therefore in the future become more effective than medicines targeted at individual proteins.

Researchers from Boston University School of Medicine (BUSM) and Boston University School of Public Health (BUSPH) have developed a method to estimate sickle cell disease severity and predict the risk of death in people with this disease. The study appears online in the June issue of the journal Blood.
Sickle cell disease is caused by mutations in the beta-hemoglobin gene (HBB). Individuals having identical pairs of genes for the HBB glu6val mutation (HbS) have sickle cell anemia; individuals with both HbS and HbC mutations have sickle cell-HbC (HbSC) disease. Both of these types of sickle cell-disease have extremely variable characteristics.

A chemically-modified version of a mitochondrial toxin long used to control species of invasive fish in lakes has been found to selectively inhibit two "survival proteins” in cancer cells. The research is a first step toward developing a molecularly-targeted drug that could eliminate cellular-level resistance to multiple types of chemotherapy and radiation therapy found in many types of cancers.
In a paper published today in the July 2007 issue of Molecular Cancer Therapeutics, scientists at Fred Hutchinson Cancer Research Center report that a modified version of antimycin called 2-Methoxy antimycin is selective in killing cells that have high levels of Bcl-2 and Bcl-xL proteins.

Researchers from the University of Pittsburgh School of Medicine report a significant new advance in the search for an effective treatment for human liver cancer in the July issue of Molecular Cancer Therapeutics.
Using a newly available monoclonal antibody, they demonstrated significant reductions in tumor cell proliferation and survival in human and mouse hepatocellular cancer (HCC) cell lines. According to the researchers, this finding has significant implications not only for the treatment of liver cancer but for a number of different types of cancer.
Most cases of HCC are secondary to either a viral hepatitis infection or cirrhosis of the liver.

Argonaute 2 (Ago2) is unique among its family: It is the only one of the four mammalian Argonaute proteins that exhibits endonuclease “slicer” activity (facilitation of miRNA-guided cleavage of target mRNA).
However, as Drs. Donal O’Carroll and Alexander Tarakhovsky (The Rockefeller Institute) report, Ago2’s defining characteristic is surprisingly non-essential for its role in hematopoiesis and miRNA biogenesis.
Drs. O’Carroll, Tarakhovsky and colleagues generated transgenic mice harboring mutated versions of Ago2 in their bone marrow. The researchers found that Ago2 is, indeed, quite necessary for normal blood cell development. Its endonulcease activity, however, is not.

Using natural ‘gravitational lenses’, an international team of astronomers claim to have found a hint of a population of the most distant galaxies yet seen - the light we see from them today left more than 13 thousand million years ago, when the Universe was just 500 million years old.
Team leader Professor Richard Ellis, Steele Professor of Astronomy at Caltech, will present images of these faint and distant objects in his talk on Wednesday 11 July at the ‘From IRAS to Herschel and Planck’ conference at the Geological Society in London.

A University of Alabama astronomer has co-developed a new way to characterize galaxy features that is giving scientists additional insight into how galaxies formed and changed over time, according to a paper published in the June 2007 issue of The Astronomical Journal.
Dr. Ronald J. Buta, professor of astronomy at UA, and Dr. Xiaolei Zhang, of the Naval Research Laboratory, Washington, D.C., co-authored the paper detailing the new method of characterizing density wave features in galaxies. Density waves are mass enhancements in galaxies that appear in the forms of spiral arms, linear bar features, and ring-shaped patterns. Orbiting stars and gas clouds stream in and out of these features much like vehicles in heavy traffic.