Why Both Stimulating And Blocking GLP-1R Helps People Lose Weight
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
A Florida State University anthropologist has new evidence that ancient farmers in Mexico were cultivating an early form of maize, the forerunner of modern corn, about 7,300 years ago - 1,200 years earlier than scholars previously thought.
Professor Mary Pohl conducted an analysis of sediments in the Gulf Coast of Tabasco, Mexico, and concluded that people were planting crops in the "New World" of the Americas around 5,300 B.C. The analysis extends Pohl's previous work in this area and validates principles of microfossil data collection.
For the first time, scientists from the University of Washington School of Medicine, Indiana University Bloomington and the University of Cambridge have determined how a plant hormone -- auxin -- interacts with its hormone receptor, called TIR1. Their report, on the cover of this week's issue of Nature, also may have important implications for the treatment of human disease, because TIR1 is similar to human enzymes that are known to be involved in cancer.
Flavonoids. You’ve heard of them -- the good-for-your-health compounds found in plants that we enjoy in red wine, dark chocolate, green tea and citrus fruits. Mother Nature is an ace at making them, producing different ones by the thousands, but no chemist has figured out a good way to synthesize a special class of these chemicals in the laboratory. Until now.
Karl Scheidt, assistant professor of chemistry in the Weinberg College of Arts and Sciences at Northwestern University, and his research team have synthesized 10 different flavanones, a type of flavonoid, using a new general method they developed that takes advantage of one simple catalyst.
There is broad consensus today that personality traits are best described by the "Big Five": Extraversion, agreeableness, conscientiousness, emotional stability, and openness to experience. Each of these broad measures can be broken down into smaller ones, but in general, this taxonomy appears to take in most of what we think of as personhood. When you think of someone as "steady" or "flaky" or "gloomy" or "daring," what you’re really doing is unconsciously taking a measure of these five traits and crunching them together.
Common practice in the treatment of adolescent eating disorder patients has been to exclude the parents. Many experts consider parents part of the problem and thus keep them away during therapy.
Two U.S.–based clinicians disagree and have written a "how to" book published in February that includes family in the treatment of these patients. They say parents are well poised to help their children overcome bulimia nervosa, a disorder characterized by binging and purging.
Texas wheat offers high quality when it comes to baking and milling characteristics, said Texas Agricultural Experiment Station's state wheat breeder.
Dr. Jackie Rudd, Experiment Station wheat breeder at Amarillo, received the annual Millers' Award from Tim Aschbrenner of Cereal Food Processors at the recent Wheat Quality Council annual meeting in Kansas City.
Oceanographers have completed an important step in constructing the first deep-sea observatory off the continental United States. Workers in the multi-institution effort laid 32 miles (52 kilometers) of cable along the Monterey Bay sea floor that will provide electrical power to scientific instruments, video cameras, and robots 3,000 feet (900 meters) below the ocean surface. The link will also carry data from the instruments back to shore, for use by scientists and engineers from around the world.
An illustration of the MARS undersea observatory shows its cabled links. Credit: David Fierstein, MBARI
University of Cincinnati (UC) neuroradiologists believe a brain imaging approach that combines standard magnetic resonance imaging (MRI) scans with specialized contrast-enhanced techniques could lead to more effective diagnoses in patients with difficult-to-detect blood clots in veins of the brain.
James Leach, MD, reports these findings in the April issue of the American Journal of Neuroradiology. This is the first study to correlate the clinical importance of data gleaned from standard MRI scans and detailed contrast-enhanced imaging techniques in patients with chronic thrombosis (blood clots) in veins of the brain.
The double sunset that Luke Skywalker gazed upon in the film "Star Wars" might not be a fantasy.
Astronomers using NASA's Spitzer Space Telescope have observed that planetary systems – dusty disks of asteroids, comets and possibly planets – are at least as abundant in twin-star systems as they are in those, like our own, with only one star. Since more than half of all stars are twins, or binaries, the finding suggests the universe is packed with planets that have two suns.
Using a laser-cooling technique that could one day allow scientists to observe quantum behavior in large objects, MIT researchers have cooled a coin-sized object to within one degree of absolute zero.
This study marks the coldest temperature ever reached by laser-cooling of an object of that size, and the technique holds promise that it will experimentally confirm, for the first time, that large objects obey the laws of quantum mechanics just as atoms do.
MIT researchers have developed a technique to cool this dime-sized mirror (small circle suspended in the center of large metal ring) to within one degree of absolute zero. Photo / Christopher Wipf
High-resolution images that reveal unexpected details of the Earth's internal structure are among the results reported by MIT and Purdue scientists in the March 30 issue of Science.
The researchers adapted technology developed for near-surface exploration of reservoirs of oil and gas to image the core-mantle boundary some 2,900 kilometers, or 1,800 miles, beneath Central and North America.
Seismic waves from earthquakes penetrate the Earth's mantle and scatter back at the core-mantle boundary to detectors on the surface. Nearly 100,000 such recordings are used to illuminate the planet's deep internal structures. Image courtesy / Robert van der Hilst, MIT
Flexible electronic membranes may overcome a longstanding dilemma faced by brain researchers: How to replicate injuries in the lab without destroying the electrodes that monitor how brain cells respond to physical trauma.
Developed by a team of engineers at Princeton University, Columbia University and the University of Cambridge, the membranes feature microelectrodes that are able to withstand the sudden stretching that is used to simulate severe head trauma. The systems could allow far more nuanced studies of brain injury than previously possible and may lead to better treatments in the minutes and hours immediately following the injury.