People who gained health coverage following the implementation of the federal Affordable Care Act's coverage expansion sharply increased their use of prescription drugs, while their out-of-pocket spending for medications dropped significantly, according to a new RAND Corporation study.

Studying the experiences of nearly 7 million prescription drug users nationally, researchers found that among those who gained private insurance there was a 28 percent increase in prescriptions filled and a 29 percent reduction in out-of-pocket spending per prescription compared to the previous year when they were uninsured.

The cell's internal skeleton undergoes constant restructuring. Ludwig-Maximilians-Universitaet (LMU) in Munich physicists now show that its associated proteins can be efficiently transported to their sites of action by diffusion - provided they can be arrested when they get there.

Investigators at the Stanford University School of Medicine and their collaborators at three other institutions have identified a novel compound that appears to exhibit painkilling power comparable to morphine but lacks that drug's most lethal property: respiratory suppression, which results in some 30,000 drug overdose deaths annually in the United States.

"This promising drug candidate was identified through an intensively cross-disciplinary, cross-continental combination of computer-based drug screening, medicinal chemistry, intuition and extensive preclinical testing," said Brian Kobilka, MD, professor of molecular and cellular physiology, and one of the senior investigators involved in the research.

Superconductivity with a high critical temperature (high Tc) continues to present a theoretical mystery. While this phenomenon is experimentally well established, no scientist has managed to explain its mechanism. In the late 90's, the British physicist Anthony Leggett proposed a scenario based on the Coulomb energy. Today, researchers at the University of Geneva (UNIGE), Switzerland, in collaboration with Leggett and his group, committed to test this scenario. Their findings challenge Leggett's conjecture, opening new avenues for the explanation of high Tc superconductivity. These results are available in the journal Physical Review X.

With temperatures soaring across the UK, our ability to detect and avoid places that are too warm is vital for regulating our body temperature. However, until now, little was known about the molecular mechanisms responsible for detecting warmth in the sensory neurons of our skin.

A new King's College London study, published today in Nature, reveals that a gene called TRPM2 initiates a 'warm' signal in mice that drives them to seek cooler environments. When this gene is removed, the mice are unable to distinguish between cool and warm temperatures.

A large screening programme has identified several genes associated with age-related conditions including hearing loss, retinal degeneration and osteoarthritis. The animal study, published in Nature Communications, may lead to studies of the equivalent human gene and help develop screening programmes to identify the risk of developing an age-related condition many years before symptoms appear.

Age is a risk factor for many conditions, including diabetes, cardiovascular disease, hearing loss, dementia and others, but the genes that we carry also influence whether we are more or less susceptible to these. Not much is known about which genes influence age-related conditions, or how they do so.