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CRISPR-Cas9: Now Knocking Out 12 Genes At Once

CRISPR-Cas9: Now Knocking Out 12 Genes At Once

Just a few short years ago, CRISPR-Cas9 technology took the world of molecular biology by storm because it allowed a cost-effective way to shut off or turn on traits in organisms without any side effects.CRISPR is an acronym of Clustered Regularly Interspaced Short Palindromic Repeats, a bacterial defense system. The enzyme Cas9 acts like a pair of ‘molecular scissors’ that can cut two strands of DNA and insert of remove something. Then CRISPR repairs it.Now it's gotten upgrade. Instead of one or two genes, a new study knocked out 12 at once.

#MeToo May Have Caused Women To Lose Out On Mentors

#MeToo May Have Caused Women To Lose Out On Mentors

Even previously considerate and helpful male managers have become less likely to mentor female employees, according to a new study. They've become less likely to even talk one-on-one with women.This unintended consequence of the #MeToo movement could deny female employees critical development and thus career advancement. Women are not the problem, a large portion of female employees report a willingness to be mentored by an older male co-worker, but career advancement also has a social component, and in the last few years men are less likely to work one-on-one in an office with the door closed and less likely to engage in social behavior, like a post-work dinner with female employees.

Like And Trust Your Doctor? It May Lead To More PSA Tests Even If The Government Wants Otherwise

Like And Trust Your Doctor? It May Lead To More PSA Tests Even If The Government Wants Otherwise

Having a single primary care physician is statistically correlated to increased treatment adherence and decreased hospital admissions and mortality risk. A new paper finds it may also lead to costly unnecessary tests. Male patients who have a single general physician were more likely to receive a prostate cancer screening test during a period when the test was not recommended by the US Preventive Services Task Force. Greedy doctors? No, the tests don't pay enough money to be meaningful, it is that doctors invariably prefer to side with patients over insurance companies or government protocols.

End Of The Uncanny Valley? The COVID-19 Pandemic Made Us Love Machines More

End Of The Uncanny Valley? The COVID-19 Pandemic Made Us Love Machines More

Whatever Uncanny Valley when it comes to machines still existed in 2019 got a lot smaller in 2020. We're even being nicer to them since 2020.People mostly dispense with social norms of human interaction and treat machines differently. The behavior holds true even as machines became more "human" seeming, such as Amazon's Alexa or Morgan Freeman in your vehicle navigation system. Human default behavior is often driven by heuristic thinking -- the snap judgments people use to navigate complex daily interactions. The Uncanny Valley says that as artificial things begin to seem more human, but not close enough to pass for human, we are put off. That all changed due to COVID-19. We got nicer toward our machine and other people.

Vaping Helps Smokers Quit - Including People With Schizophrenia

Vaping Helps Smokers Quit - Including People With Schizophrenia

Schizophrenia can cause hallucinations, delusions, trouble with thinking and other behaviors that impact daily functioning. Though it affects less than 1% of the public, 60% of schizophrenic smoke cigarettes, a known carcinogen and risk factor for numerous diseases; a 500 percent increase over the general population, where smoking has plummeted thanks to greater awareness of its harms plus smoking cessation tools like nicotine gums, patches, and vaping.

Beta Blockers Don't Cause Depression

Beta Blockers Don't Cause Depression

Beta-blockers are a class of medications that reduce the heart rate, the heart's workload and the heart's output of blood, which, together, lower blood pressure.Blood pressure is only a risk factor for heart disease, it is not a disease in itself, yet when people hear about a medical issue with a vital organ it can have profound psychological impacts. Some people report feeling depressed or having fitful sleep after taking beta blockers. Plus anxiety, drowsiness, hallucinations and nightmares. When one medicine has so many diverse correlations without any biological plausibility, it is probably not the medicine, it is more likely the implications of the medicine.

46% Of Parents Say Responses To The COVID-19 Pandemic Damaged Teen Mental Health

46% Of Parents Say Responses To The COVID-19 Pandemic Damaged Teen Mental Health

For as much talk as there is about bullying and drama in schools, for most teens the experience of interacting with peers is not only positive, it is essential training for dealing with others later in life.And if a new national poll is an indication, government lockdowns and societal pressure during the COVID-19 pandemic may have lasting impacts on the mental health of young people.

What Are Noeggerathiales? Read This And Find Out

What Are Noeggerathiales? Read This And Find Out

In Mongolia, plants preserved in a volcanic ash fall deposit as part of a so-called "vegetational Pompeii," may have resolved the mystery of the Noeggerathiales.What are Noeggerathiales? Paleontologists have wanted to really know since they first learned of them.Scientists know they were peat-forming plants that lived approximately 325-251 million years ago but their relationships with other plant groups was unknown. Were they an evolutionary dead end? Now it has been established that Noeggerathiales had the spore propagation mode of ferns and the vascular tissue of seed plants. They belonged to a sister group of seed plants, the former gymnosperm.

COVID-19 Variant B.1.1.7 Statistics Suggest Higher Mortality

COVID-19 Variant B.1.1.7 Statistics Suggest Higher Mortality

COVID-19 caused by SARS-CoV-2 variant, B.1.1.7 was first discovered in Kent last year and statistics suggest it is 30 and 100 percent more deadly than previous strains.This is epidemiology, so an exploratory finding using correlation, that is why the range is so large. Scientists would have to confirm the validity of the statistical correlation before figuring out how to tackle it.

Singlet Fission May Solve The Solar Efficiency Problem

Singlet Fission May Solve The Solar Efficiency Problem

In lab tests, solar often seems to work great, yet in actual use its efficiency drops sharply. A phenomenon known as singlet fission can help but it is hindered by unexplained energy losses during the reaction.Basic research is needed because solar energy could grow to be one of the most important fossil-free and eco-friendly sources of electricity. Unless it doesn't work as advertised for taxpayers who fund it.

Binarized Transcriptome Aging Clock Reads Biological Age Directly From Gene Expression

Binarized Transcriptome Aging Clock Reads Biological Age Directly From Gene Expression

We all have an age but we also know time is a relative abstract construct based on real dimensions in the physical world; a day is different on Mars than it is on Earth. We know our birthdays and how old we are but it does not tell us how long we might live.Some people age faster than others and a new study hopes to be able to measure the transcriptome, gene expression, and create a true way to read biological clocks. This study was with the model organism Caenorhabditis elegans, and worms are not little people, but for the last four decades it has become vital for studying DNA and genomes. 

Homeostasis And The Math Of Human Biology

Homeostasis And The Math Of Human Biology

Outside extreme temperature environments, our body temperatures remain around 98.6 degrees Fahrenheit, no matter how hot or cold the. For most people, the sugar levels in our blood remain fairly constant even after drinking a glass of orange juice, which is essentially a vitamin-fortified sugar-filled soda. Most of us keep the right amount of calcium in our bones and out of the rest of our bodies.Our bodies are good at that kind of self-regulation, known as homeostasis, and scientists have a good handle on the biological reasons why that regulation happens: Certain systems in our bodies have to remain constant in order to function and keep our bodies alive.