A recent randomized trial looked at the feasibility of 2013 guidelines issued by the American College of Surgeons Trauma Quality Improvement Project for trauma resuscitation and found that delivering universal donor plasma to massively hemorrhaging patients can be accomplished consistently and rapidly and without excessive wastage in high volume trauma centers.

The plasma is given in addition to red blood cell transfusions to optimize treatment. 
Injury is the leading cause of death among young adults, and uncontrolled hemorrhage is the most important preventable factor among those who sustain traumatic injury.

The 2013 guidelines recommend that universal donor products be immediately available on arrival of severely injured patients, and they represent a major shift in the paradigm of trauma resuscitation and blood product provision that has existed for more than a generation.

Those recommendations are currently outside the capabilities of many facilities, due to the expense of maintaining even a small thawed plasma inventory, but they are likely to become the expected standard in the near future.

"We hope the descriptions of the various ways in which centers fulfilled the requirement of delivering blood components to the bedside within 10 minutes inspire other facilities to devise the most effective way for their own circumstances," said Dr. Deborah Novak, lead author of the Transfusion paper.