CRISPR/Cas systems for genome editing have revolutionized biological research over the past three years, and their ability to make targeted changes in DNA sequences in living cells with relative ease and affordability is now being applied to clinical medicine and will have a significant impact on advances in drug and other therapies, agriculture, and food products.

The power and promise of this innovation are presented in the Review article "The Bacterial Origins of the CRISPR Genome-Editing Revolution published in Human Gene Therapy. 

Researchers have completed a large-scale research project conducted over a five-year period on the African continent to compile the first greenhouse gas budget of African rivers.

Covering 12 rivers spread across the entire continent of Africa, the study shows that greenhouse gas emissions from the rivers are very significant. The researchers trawled the African continent in order to analyze the streams of carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O), the three main GHG.

A new study has found that long-term stimulant abuse had more significant effects on brain volume in women compared with men.

The researchers sought to determine how the brains of people previously dependent on stimulants were different from the brains of healthy people. 

The researchers analyzed structural brain magnetic resonance imaging exams in 127 men and women, including 59 people (28 women and 31 men) who were previously dependent on cocaine, amphetamines and/or methamphetamine for an average of 15.7 years, and 68 people (28 women and 40 men) who were similar in age and were not previously dependent on those drugs.

Healing times for skin ulcers and bedsores can be reduced by a third with the use of low-intensity ultrasound - ultrasound transmits a vibration through the skin and wakes up cells in wounds helping to stimulate and accelerate the healing process. 

More than 200,000 patients in the UK suffer with chronic wounds every year at a cost of over £3.1 billion to the NHS, according to background information in the article. The ultrasound treatment, which also reduces the chance of wounds getting infected, is particularly effective when treating diabetics and the elderly. 

According to the World Health Organization, clinical depression carries the second heaviest burden of disability among all medical conditions worldwide (around 350 million people) and accounts for more than 8 percent of all U.S. years lived with disability. 

The findings of a recent study could potentially lead to new ways to predict risk for depression and treatments for the disease, using genome-wide association studies. 

Surgeries related to overuse elbow injuries, i.e. Tommy John Surgery, are more common among youth athletes than previously believed, according to research presented last week at the American Orthopaedic Society for Sports Medicine's (AOSSM) Annual Meeting in Orlando.

"Our results showed that 15-19 year-olds accounted for 56.7 percent of the Ulnar Collateral Ligament Reconstruction (UCLR) or Tommy John surgeries performed in the U.S. between 2007-2011. This is a significant increase over time with an average increase of 9.12 percent per year," said lead author, Brandon Erickson, MD of Rush University Medical Center in Chicago, Illinois.