A research group has made a breakthrough discovery which could help thousands of young girls worldwide who are suffering from a rare yet debilitating form of epilepsy. The United States pharmaceutical company Marinus Pharmaceuticals is now recruiting affected girls as part of the world's first clinical trial to test the therapy. 

Professor Jozef Gecz, from the University of Adelaide's Robinson Research Institute, was a key player in identifying the responsible gene and mutations in this female-only epileptic syndrome, in 2008 and has now found a treatment for this disorder.

One of the questions raised by the prospect of climate change is whether it could cause more species of animals to interbreed. Two species of flying squirrel have already produced mixed offspring and those have somehow been blamed on climate change, along with a hybrid polar bear and grizzly bear cub (known as a grolar bear, or a pizzly). 

A paper in Nature Climate Change tallies the potential number of such pairings and across North and South America it estimates that only about 6 percent of closely related species whose ranges do not currently overlap are likely to come into contact by the end of this century. 

One Shake Shack French fry may lead you to eat a whole batch, and don't even get started on the power of Doritos. According to a new study using rats, that high-fat indulgence literally changes the populations of bacteria residing inside the gut and also alters the signaling to the brain.

The result? The brain no longer senses signals for fullness, which can cause overeating--a leading cause of obesity. 

The findings presented this week at the Annual Meeting of the Society for the Study of Ingestive Behavior liken a high fat diet to how a sudden significant shift in temperature might impact the people who live in the affected area: Some people will be fine. Others will become ill.

Each cell in the body contains a whole genome, 3 billion of "letters" known as bases, so the data packed into a few DNA molecules could fill an entire hard drive.

Instead of having one reference genome for study, more and more people are having their DNA sequenced, and that is a truly massive amount of data that will require massive computational and storage capabilities beyond anything previously anticipated, says a new assessment from computational biologists and computer scientists at the University of Illinois and Cold Spring Harbor Laboratory.

It is well established that volcanic eruptions contribute to climate variability but quantifying those impacts has proven challenging due to inconsistencies in historic atmospheric data observed in ice cores and corresponding temperature variations seen in climate proxies such as tree rings.

A new study in Nature resolves those inconsistencies with a new reconstruction of the timing and associated radiative forcing of nearly 300 individual volcanic eruptions extending as far back as the early Roman period.

A mutation found in most melanomas rewires cancer cells' metabolism, making them dependent on a ketogenesis enzyme, researchers at Winship Cancer Institute of Emory University have discovered. The finding points to possible strategies for countering resistance to existing drugs that target the B-raf V600E mutation, or potential alternatives to those drugs. It may also explain why the V600E mutation in particular is so common in melanomas.

The growth-promoting V600E mutation in the gene B-raf is present in most melanomas, and also in some cases of colon and thyroid cancer. Drugs such as vemurafenib are available that target this mutation, but in clinical trials, after a period of apparent remission, cancers carrying the V600E mutation invariably develop drug resistance.