Is there sex-specific epigenetic regulation of fear memory?A new study says yes, for mice anyway, and if it later is found to be similar in humans it could explain why fear and stress-related disorders affect men and women differently. Fear and memory produce changes to genes that modulate gene expression, called epigenetic modifications, some contend. In a mouse model of traumatic memory, epigenetic activation of
gene important for creating fear memories and stress behavior, called cyclin dependent kinase 5 (Cdk5)
increased naturally in males, but not in females, after the mice recalled a fear-related memory.