Why Both Stimulating And Blocking GLP-1R Helps People Lose Weight
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
Researchers from the University of Barcelona and the University of California, San Francisco have captured the first high resolution images of DNA unfolding. The team studied a small DNA fragment consisting of 12 base pairs (the human genomes has about 3,000 million base pairs) and obtained 10 million structural snapshots of how DNA unfolds. In this process they revealed the two main ways by which the natural folded structure move to an unfolded state. The results of the research were published in Angewandte Chemie.
Listening to music based on the genre it belongs to may lead you away from songs or albums you would actually enjoy, say the authors of a study in the New Journal of Physics. The research shows that searching for the temporal aspects of songs – their rhythm – might be a better way to find music you like than using current automatic genre classifications.By studying similar and different characteristics of specific rhythmic durations and the occurrence of rhythmic sequences, the group of Brazilian researchers found that it is possible to correctly identify the musical genres of specific musical pieces.
An innovative paint system may make it possible to lower the fuel consumption of airplanes and ships, reducing costs and carbon dioxide emissions, according to researchers at the Fraunhofer Institute for Manufacturing Engineering and Applied Materials Research. When applied to every airplane every year throughout the world, the paint could save a volume of 4.48 million tons of fuel.The inspiration for the paint's structure comes from the scales of fast-swimming sharks that have evolved in a manner that significantly diminishes drag. The challenge was to apply this knowledge to a paint that could withstand the extreme demands of aviation. Temperature fluctuations of -55 to +70 degrees Celsius; intensive UV radiation and high speeds.
Researchers writing in Current Biology say they may have determined what makes musical notes sound good (or bad) by studying the preferences of more than 250 college students from Minnesota to a variety of musical and nonmusical sounds.
WASP-12b is the hottest known planet in the Milky Way galaxy, and it may also be the shortest-lived. The planet is being eaten by its parent star, according to observations made by a new instrument on NASA's Hubble Space Telescope, the Cosmic Origins Spectrograph (COS). The planet may only have another 10 million years left before it is completely devoured. The discovery has been documented in The Astrophysical Journal Letters. WASP-12 is a yellow dwarf star located approximately 600 light-years away in the winter constellation Auriga. The exoplanet was discovered by the United Kingdom's Wide Area Search for Planets (WASP) in 2008. The automated survey looks for the periodic dimming of stars from planets passing in front of them, an effect called transiting.
Scientists have developed the first cell controlled by a synthetic genome which may allow them to probe the basic machinery of life and engineer bacteria specially designed to solve environmental or energy problems.The research team, led by Craig Venter, has already chemically synthesized a bacterial genome, and transplanted the genome of one bacterium to another. Now, the scientists have put both methods together, to create what they call a "synthetic cell," although only its genome is synthetic.
Albert Einstein said scientists would never be able to observe the instantaneous velocity of tiny particles as they randomly shake and shimmy, so called Brownian motion, but physicist at the University of Texas say they have done so.In 1907, Einstein likely did not foresee a time when dust-sized particles of glass could be trapped and suspended in air by dual laser beam "optical tweezers." Nor would he have known that ultrasonic vibrations from a plate-like transducer would shake those glass beads into the air to be tweezed and measured as they moved in suspension.
Heavy alcohol consumption carries a lot of significant health risks, and researchers from the University of Texas say men who drink too much face a higher risk of pancreatic cancer.In a study published in Cancer Causes and Control, researchers found that the more alcohol a man consumed, the higher his risk of pancreatic cancer compared with those who drank little or no alcohol.Men who consumed alcohol increased their risk of pancreatic cancer by 1.5 to 6 times compared with those who didn't consume alcohol or who had less than one drink per month. The increased risk depended on the amount and frequency of alcohol consumption. Researchers found that the risk was greater no matter when in the past heavy drinking occurred.
Data from the ESA's Envisat radar satellite shows that the Gulf of Mexico Oil Spill has entered the Loop Current, a powerful conveyor belt that flows clockwise around the Gulf of Mexico towards Florida."With these images from space, we have visible proof that at least oil from the surface of the water has reached the current," said Dr Bertrand Chapron of Ifremer, the French Research Institute for Exploitation of the Sea.Dr Chapron and Dr Fabrice Collard of France's CLS have been combining surface roughness and current flow information with Envisat Advanced Synthetic Aperture Radar (ASAR) data of the area to monitor the proximity of the oil to the current.
The global climate trend since Nov. 16, 1978 is +0.14 C per decade, according to scientists from the Earth System Science Center (ESSC) at The University of Alabama in HuntsvilleApril temperatures (preliminary)Global composite temp.: +0.50 C (about 0.9 degrees Fahrenheit) above 20-year average for April.Northern Hemisphere: +0.80 C (about 1.44 degrees Fahrenheit) above 20-year average for April.Southern Hemisphere: +0.21 C (about 0.38 degrees Fahrenheit) above 20-year average for April.Tropics: +0.63 C (about 1.34 degrees Fahrenheit) above 20-year average for April.March temperatures (revised):Global Composite: +0.66 C above 20-year average
Spices commonly used to season cooked ground beef may also reduce the risk of consuming compounds called heterocyclic amines (HCAs) that can cause cancer .HCAs are the carcinogenic compounds that are produced when muscle foods, such as ground beef patties, are barbecued, grilled, boiled or fried. Consuming HCAs through meat increases risk factors for colorectal, stomach, lung, pancreatic, mammary and prostate cancers.J. Scott Smith, a Kansas State University food chemistry professor, found that certain spices containing natural antioxidants would reduce HCA levels by 40 percent when applied to beef patties during cooking.
The widely held notion that warming global temperatures will lead to a future intensification of malaria and an expansion of its global range is at odds with the available evidence, according to a new study in Nature.The research, conducted by the Malaria Atlas Project (MAP), suggests that current interventions could have a far more dramatic – and positive – effect on reducing the spread of malaria than any negative effects caused by climate change.A steady stream of modeling studies have predicted that malaria will worsen and its range will spread as the world gets warmer.