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Multitasking Proteins: Unexpected Properties Of Galectin-3

Multitasking Proteins: Unexpected Properties Of Galectin-3

A new study, published in Biochemistry this week, examines the biomechanics of sugar-seeking proteins. Specifically, it delves into galectin-3's interaction with glycosaminoglycans (GAG) and proteoglycans. Tarun Dam, an associate professor of chemistry at Michigan Technological University, led the study.
"Seeing galectin-3 interact with GAGs and proteoglycans is like finding a rose in the petunias--it's very unexpected," Dam says. "It's fair to say that this requires revisiting the reported biological functions of GAGs, proteoglycans and galectin-3."

Sunflowers Move By The Clock

Sunflowers Move By The Clock

It's summertime, and the fields of Yolo County are filled with ranks of sunflowers, dutifully watching the rising sun. At the nearby University of California, Davis, plant biologists have now discovered how sunflowers use their internal circadian clock, acting on growth hormones, to follow the sun during the day as they grow.
"It's the first example of a plant's clock modulating growth in a natural environment, and having real repercussions for the plant," said Stacey Harmer, professor of plant biology at UC Davis and senior author on the paper to be published Aug. 5 in the journal Science.

Goodbye, Implants Rejection!

Goodbye, Implants Rejection!

A group of Russian physicists, with the contribution from their Swiss colleagues, developed a way to use the therapeutic effect of heating or cooling the tissues due to the magnetocaloric effect. The article with the results of the work was published in the latest issue of the International Journal of Refrigeration.
A team of the Lomonosov Moscow State University scientists proposed a new way to use the magnetocaloric effect for the targeted delivery of drugs to the implants. Vladimir Zverev, one of the authors (Lomonosov Moscow State University, Faculty of Physics) claims that this is a unique method that uses a negative magnetocaloric effect.

Vaccine Candidates Protect Against Zika Virus In Rhesus Monkeys

Vaccine Candidates Protect Against Zika Virus In Rhesus Monkeys

SILVER SPRING, Md. - The Walter Reed Army Institute of Research (WRAIR), in collaboration with the Beth Israel Deaconess Medical Center and Harvard Medical School, has completed a second round of preclinical studies on a promising Zika vaccine candidate and found it to completely protect rhesus monkeys from experimental infection with Zika virus.

Vitamin D Levels May Drop When Women Stop Using Birth Control

Vitamin D Levels May Drop When Women Stop Using Birth Control

Washington, DC--Women risk having their vitamin D levels fall when they stop using birth control pills or other contraceptives containing estrogen, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.
Vitamin D is a hormone involved in the immune system and managing calcium levels in the blood. Proper calcium levels are necessary for bone health.

Nearly Half Of Pediatric Clinical Trials Go Unfinished Or Unpublished

Nearly Half Of Pediatric Clinical Trials Go Unfinished Or Unpublished

Recent legislation is encouraging clinical trials in children, including the Best Pharmaceuticals for Children Act and the Pediatric Research Equity Act. Yet clinical trials in children commonly go either uncompleted or unpublished, finds a comprehensive study conducted by researchers at Boston Children's Hospital. Results were published online August 4 by the journal Pediatrics.
In all, 19 percent of trials were discontinued early, and 30 percent of completed trials remained unpublished in the medical literature several years later. "We feel there is a lot of inefficiency and waste that could be addressed," says senior investigator Florence Bourgeois, MD, MPH, of Boston Children's Hospital.

Vitamin A Metabolism Is Linked To Eye Tissue Fibrosis And Scarring

Vitamin A Metabolism Is Linked To Eye Tissue Fibrosis And Scarring

Mucous membrane pemphigoid is an autoimmune disease that causes inflammation and scarring in mucosal tissues. Affected individuals frequently exhibit scarring in the eye, which can lead to blindness in as many as 20% of patients. In this issue of JCI Insight, two related studies report on the underlying cause of fibrosis in the eye and implicate an important role for vitamin A metabolism. A group of researchers led by John Dart at UCLA show that the enzyme aldehyde dehydrogenase (ALDH), which produces the vitamin A metabolite retinoic acid, is elevated in mucous membrane tissue in the eye from mucous membrane pemphigoid patients.

Adaptation To Climate Risks: Political Affiliation Matters

Adaptation To Climate Risks: Political Affiliation Matters

A new study reveals that those who affiliate with the Democratic Party have different views than those who vote Republican on the following issues: the likelihood of floods occurring, adopting protection measures, and expectations of disaster relief from the government. The study was jointly conducted by VU University in Amsterdam, Utrecht University School of Economics in The Netherlands, and the Center for Risk Management and Decision Processes at the Wharton School of the University of Pennsylvania in Philadelphia, USA.

Smiling Baby Monkeys And The Roots Of Laughter

Smiling Baby Monkeys And The Roots Of Laughter

Kyoto, Japan -- When human and chimp infants are dozing, they sometimes show facial movements that resemble smiles. These facial expressions -- called spontaneous smiles -- are considered the evolutionary origin of real smiles and laughter.
Researchers at Kyoto University's Primate Research Institute show that this not only happens to higher-order primates like humans and chimpanzees, but also in newborn Japanese macaques, which are more distant relatives in the evolutionary tree.

Genomics Study Points To Origins Of Pollen Allergens

Genomics Study Points To Origins Of Pollen Allergens

A joint University of Adelaide-Shanghai Jiao Tong University study has provided the first broad picture of the evolution and possible functions in the plant of pollen allergens.
Published in the journal Plant Physiology, the researchers believe their work may help with medical research into the reduction or prevention of allergic diseases such as asthma and allergic rhinitis (hay fever).
"During the past four decades, allergic diseases have become a global health problem," says project leader Professor Dabing Zhang, who leads the University of Adelaide and Shanghai Jiao Tong University Joint Laboratory for Plant Science and Breeding.

Honey Bee Colonies Had A Worse Than Average Winter - But Don't Buy Hype About It

Honey Bee Colonies Had A Worse Than Average Winter - But Don't Buy Hype About It

The number of honey bee colonies fell by nearly 12% last winter - according to a preliminary look at a survey of beekeepers, that is. The UK and Spain were worst affected this year. The prior year, other areas of Europe were hardest hit.  While environmental groups make money scaring people about that, what it really means is something else.
The preliminary claims are being made by the honey bee research association COLOSS, based in the Institute of Bee Health at the University of Bern.