A new review examines the potential of antioxidant approaches for the treatment of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis.
Certain compounds that are involved in oxidative stress look like promising therapeutic targets. For example, researchers are investigating the potential of increasing antioxidant capacity by targeting what's known as the Nrf2 pathway, as well as developing inhibitors of NADPH oxidases, which are key sources of reactive oxygen species. Other potential strategies for limiting oxidative stress in neurodegenerative diseases include reducing the production of nitric oxide, or preventing mitochondrial dysfunction.