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Cancer Cell Lines Predict Drug Response

Cancer Cell Lines Predict Drug Response

7 July 2016 - New research shows that patient-derived cancer cell lines harbour most of the same genetic changes found in patients' tumours, and could be used to learn how tumours are likely to respond to new drugs. The findings, published in Cell, will help to increase the success rate for developing new, more personalised cancer treatments.

Neural Networks To Obtain Synthetic Petroleum

Neural Networks To Obtain Synthetic Petroleum

Biomass is one of the main sources of energy and heat in the field of renewable energy production: it is any type of non-fossil organic matter, such as living plants, timber, agricultural and livestock waste, wastewater, solid urban organic waste, etc. The three most developed technologies for obtaining energy from biomass are as follows: pyrolysis (decomposition by heating in the absence of oxygen), gasification (reaction with air, oxygen or a blend of both and conversion into gas) and combustion (decomposition through heating with oxygen). The effectiveness and emission levels of these three processes change depending on the composition of the biomass as well as its properties, the experimental conditions and equipment used.

Cost Doesn't Matter, Almost Half Of Popular Sunscreens Don't Offer Adequate Protection

Cost Doesn't Matter, Almost Half Of Popular Sunscreens Don't Offer Adequate Protection

Jessica Alba's "Honest" company has been criticized for being frauds but it's not alone. Though the variation in cost for sunscreen protection averages well over 3,000, the variation is protection is not very much.
Like with organic food, you don't get what you pay for - unless what you are paying for is self-identification. But no matter what you pay or why you buy, you may not be getting a product that meets the American Academy of Dermatology's guidelines for sunscreens. This was largely due to a lack of water or sweat resistance, according to a new Northwestern Medicine study.

Lessons Of Lager: Yeast Is Science Even Organic Food Shoppers Appreciate

Lessons Of Lager: Yeast Is Science Even Organic Food Shoppers Appreciate

Beer is the world's most commonly fermented beverage and lager beer commands 94 percent of the global market. Making the beer possible is a biological oddity: a hybrid yeast that combines two distinct species and confers the ability to make cold-brewed beer, a product that first emerged 500 years ago in Europe.
 Without question, the domesticated hybrid yeast that gives us lager beer is an organism worth many billions of dollars, but just how Saccharomyces cerevisiae, the well-known domesticated yeast that gives us wine and bread, combined with Saccharomyces eubayanus, a yeast species only recently discovered in nature, to give us the hybrid organism that makes cold-brewed beer remains a mystery.

How To Get Moral Free-Riders To Cooperate: Make Everyone Pre-Pay

How To Get Moral Free-Riders To Cooperate: Make Everyone Pre-Pay

Moral judgments, ideas about good or bad, remain the building block of cooperation in a large group.
A rule of thumb for promoting cooperation is to help those who have a good reputation and not those who have a bad reputation, yet that determination requires time, effort and money. What about moral "free riders" who evade the cost associated with moral judgment (e.g. by not paying taxes for police and court) so are better off than those who shoulder the cost?
Philosophers debate voluntary reactive policing of the moral free riders, which is costly, too, and thus can be exploited by higher order moral free riders. This leads to an infinite regression of opportunities to free ride.
Can the moral free rider problem really be solved? 

NHS England Should Fund PrEP For HIV Prevention

NHS England Should Fund PrEP For HIV Prevention

It is time for NHS England to "do the right thing" and fund pre-exposure prophylaxis (PrEP) for HIV prevention, argue two senior public health doctors in The BMJ today.
Directors of public health Jim McManus and Dominic Harrison, say despite overwhelming evidence that PrEP against HIV infection is largely safe, effective, and cost effective, NHS England has declined to make it available on the NHS, arguing that HIV prevention is the responsibility of local government.
Such an approach, they write, "confounds its advocacy of a health and care system integrated around the best outcomes for the citizen and perpetuates an incoherent national approach to HIV prevention."

Subsidized Food Linked To More Calories, And More Cardiometabolic Risks

Subsidized Food Linked To More Calories, And More Cardiometabolic Risks

Current federal agricultural subsidies focus on financing production of food commodities, a large portion of which are converted into high-fat meat and dairy products, refined grains, high-calorie juices and soft drinks (sweetened with corn sweeteners), and processed and packaged foods.
Karen R. Siegel, Ph.D., of the Centers for Disease Control and Prevention, Atlanta, and coauthors used data from the National Health and Nutrition Examination Survey from 2001 to 2006 to calculate an individual-level "subsidy score" for consumption of subsidized food commodities as a percentage of total calorie intake.
The study, which relied on a single day of 24-hour dietary recall, included 10,308 participants, about half of whom were men, with an average age of about 40.

To These Flies, Cicada Sounds Are Like Love Songs

To These Flies, Cicada Sounds Are Like Love Songs

In the insect world, smells are important. Insects of course do not have noses, but they do have receptors on their antennae, feet, and other body parts that allow them to sense chemicals and odors.
Female parasitoid wasps and flies are known to hone in on their hosts (caterpillars, cicadas, and other insects and arthropods) by "smelling" them -- that is, they sense chemicals from other insects that attract them. Once they find the hosts, they lay eggs on or inside them, and the young that emerge from the eggs feed on them.

Warming Pulses In Ancient Climate Record Link Volcanoes, Asteroid Impact And Dinosaur-killing Mass

Warming Pulses In Ancient Climate Record Link Volcanoes, Asteroid Impact And Dinosaur-killing Mass

ANN ARBOR -- A new reconstruction of Antarctic ocean temperatures around the time the dinosaurs disappeared 66 million years ago supports the idea that one of the planet's biggest mass extinctions was due to the combined effects of volcanic eruptions and an asteroid impact.
Two University of Michigan researchers and a Florida colleague found two abrupt warming spikes in ocean temperatures that coincide with two previously documented extinction pulses near the end of the Cretaceous Period. The first extinction pulse has been tied to massive volcanic eruptions in India, the second to the impact of an asteroid or comet on Mexico's Yucatan Peninsula.

Could Goats Become Man's Best Friend?

Could Goats Become Man's Best Friend?

Goats have the capacity to communicate with people like other domesticated animals, such as dogs and horses, according to scientists from Queen Mary University of London (QMUL).
In a new paper in the journal Biology Letters, researchers from QMUL's School of Biological and Chemical Sciences found that goats respond to people by gazing at them when facing a problem they cannot solve alone, and their responses change depending on the person's behaviour.
To investigate, the team trained goats to remove a lid from a box to receive a reward. In the final test, they made the reward inaccessible and recorded their reaction towards the experimenters, who were either facing the goats or had their backs to them.

Reconstruction Of 12,000 Year Old Funeral Feast Brings Ancient Burial Rituals To Life

Reconstruction Of 12,000 Year Old Funeral Feast Brings Ancient Burial Rituals To Life

The woman was laid on a bed of specially selected materials, including gazelle horn cores, fragments of chalk, fresh clay, limestone blocks and sediment. Tortoise shells were placed under and around her body, 86 in total. Sea shells, an eagle's wing, a leopard's pelvis, a forearm of a wild boar and even a human foot were placed on the body of the mysterious 1.5 meter-tall woman. Atop her body, a large stone was laid to seal the burial space.

Mixing Cannabis With Tobacco Increases Dependence Risk, Suggests Study

Mixing Cannabis With Tobacco Increases Dependence Risk, Suggests Study

Tobacco and cannabis are two of the world's most popular drugs, used respectively by 1 billion and 182 million people worldwide (World Health Organization; United Nations Office on Drugs and Crime). The adverse health effects of tobacco are well known. Short-term effects of cannabis are transient impairments in motor function and working memory, planning, and decision-making, while possible long-term health effects of heavy cannabis use include physical and psychological dependence, permanent reductions in cognitive performance, cardiovascular and respiratory diseases, and some cancers (WHO).