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Study Finds Metforin Kills Cancer Cells That Lack P53 Gene

Study Finds Metforin Kills Cancer Cells That Lack P53 Gene

Metforin, the most commonly prescribed diabetes drug, kills tumor cells that lack key regulatory gene p53, according to a new study by researchers at the University of Pennsylvania School of Medicinr.
More than half of all human cancers have lost the p53 gene. Yet even in an era of molecularly targeted therapies scientists have had trouble figuring out how to compensate for the absence of a gene. Unlike a genetic mutation that changes the function or activity of a gene, which can be inhibited by a well-tailored drug, loss of a gene leaves nothing for the drug to target.
“This is the first time you can show that tumor growth is impaired by a diabetes drug,” says senior author Craig B.

New Model Dashes Hopes Of Life On Enceladus

New Model Dashes Hopes Of Life On Enceladus

Life on Saturn's icy moon? Unlikely, say University of Illinois researchers, and a new model they have created shows it is possible for a frigid, stiff Enceladus without a shifting interior (such as plate tectonics on Earth) to develop fractures and ridges, and convey heat at the rate observed by the Cassini spacecraft since 2004, without liquid water.
The Cassini spacecraft revealed a south polar region of Enceladus with an elaborate arrangement of fractures and ridges, heat radiation and geyser-like plumes consisting of ice crystals and gases such as methane, nitrogen and carbon dioxide.

Why We Have Trouble Distinguishing Faces Of Other Races

Why We Have Trouble Distinguishing Faces Of Other Races

"They all look the same" is a common expression regarding people of other races.
The “cross-race effect” is one of the most well replicated findings in psychological research and is one reason for the disturbingly common occurrence of eye-witness misidentifications.
The causes of the cross-race effect are unclear. Some psychologists argue that inherent segregation means some people don’t have much practice with individuals of other racial groups and are thus less capable of recognizing distinguishing features. Researchers from Miami University have a different idea. They argue this effect arises from our tendency to categorize people into in-groups and out-groups based on social categories like social class, hobbies, and of course, race.

RESOLUT Duplicates Supernova Conditions

RESOLUT Duplicates Supernova Conditions

For the past few months, members of the department of physics at Florida State University have begun using a groundbreaking new research facility to conduct experiments that may help provide answers to just such questions.
RESOLUT -- short for "REsonator SOLenoid with Upscale Transmission" -- is the name of the facility, which is located within the John D. Fox Superconducting Accelerator Laboratory on the FSU campus.

Vision Restoration Therapy Also Improves Brain Damage

Vision Restoration Therapy Also Improves Brain Damage

Columbia University Medical Center researchers have demonstrated using functional magnetic resonance imaging (fMRI), that brain activity was increased in stroke and traumatic brain injury survivors who underwent Vision Restoration Therapy (VRT), a rehabilitative treatment that helps these patients recover lost vision.
Researchers, led by Randolph S. Marshall, M.D., M.S., associate professor of clinical neurology at Columbia University, examined the fMRIs of six patients aged 35-77 with vision loss on the same side of both eyes (called homonymous hemianopia) caused by stroke or traumatic brain injury.

Range, Severity Of Phoma Stem Canker Increased By Global Warming

Range, Severity Of Phoma Stem Canker Increased By Global Warming

A paper published in the Royal Society journal Interface on 15th August 2007 highlights recent research that predicts that the range and severity of the plant disease phoma stem canker is increased by global warming.
A research team led by Rothamsted Research has used a weather-based model developed to predict the start and severity of epidemics of phoma stem canker, a disease of oilseed rape and other brassicas that causes losses of $900M worldwide, to investigate the consequences of predicted climate change scenarios.

Comets Reveal Evidence Of Origin Of Life, Scientists Claim

Comets Reveal Evidence Of Origin Of Life, Scientists Claim

Recent probes inside comets show it is overwhelmingly likely that life began in space, according to a new paper by Cardiff University scientists.
Professor Chandra Wickramasinghe and colleagues at the University’s Centre for Astrobiology have long argued the case for panspermia - the theory that life began inside comets and then spread to habitable planets across the galaxy. A recent BBC Horizon documentary traced the development of the theory.
Now the team claims that findings from space probes sent to investigate passing comets reveal how the first organisms could have formed.

Beyond batteries: Storing power in a sheet of paper

Beyond batteries: Storing power in a sheet of paper

Researchers at Rensselaer Polytechnic Institute have developed a new energy storage device that easily could be mistaken for a simple sheet of black paper.
The nanoengineered battery is lightweight, ultra thin, completely flexible, and geared toward meeting the trickiest design and energy requirements of tomorrow’s gadgets, implantable medical equipment, and transportation vehicles.
Along with its ability to function in temperatures up to 300 degrees Fahrenheit and down to 100 below zero, the device is completely integrated and can be printed like paper. The device is also unique in that it can function as both a high-energy battery and a high-power supercapacitor, which are generally separate components in most electrical systems.

Invasion Of The Brain Tumors

Invasion Of The Brain Tumors

The invasive nature of cancers in general, and malignant gliomas in particular, is a major clinical problem rendering tumors incurable by conventional therapies.
Using a novel invasive glioma mouse model established by serial in vivo selection, new research has identified the p75 neurotrophin receptor (p75NTR) as a critical regulator of glioma invasion.

Pollution Causes 40 Percent Of Deaths Worldwide, Study Finds

Pollution Causes 40 Percent Of Deaths Worldwide, Study Finds

About 40 percent of deaths worldwide are caused by water, air and soil pollution, concludes David Pimentel, Cornell professor of ecology and agricultural sciences.
Such environmental degradation, coupled with the growth in world population, are major causes behind the rapid increase in human diseases, which the World Health Organization has recently reported. Both factors contribute to the malnourishment and disease susceptibility of 3.7 billion people, he says.
Pimentel and a team of Cornell graduate students examined data from more than 120 published papers on the effects of population growth, malnutrition and various kinds of environmental degradation on human diseases.

Does Renewable Energy Make Sense?

Does Renewable Energy Make Sense?

Do the overall efficiencies of renewable energy sources, such as wind, solar, and geothermal add up in terms of their complete life cycle from materials sourcing, manufacture, running, and decommissioning? Researchers in Greece have carried out a life cycle assessment to find the answer.
Increasing energy consumption and a growing world population implies shrinking reserves of fossil fuels. While the use of fossil fuels brings with it the problem of carbon dioxide emissions and climate change. Continued dependence on fossil fuels coupled with the pressing global issue of climate change has pushed the concept of renewable energy sources to the top of the agenda.