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Phase 2 data showing a reduction in amyloid-beta plaques in early Alzheimer's patients is good enough for FDA to give it temporary approval under their Accelerated Approval pathway.The positive results occurred in mild cognitive impairment or mild dementia patients. Lecanemab-irmb is a 100 mg/mL injection for intravenous use, a humanized immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against aggregated soluble (“protofibril”) and insoluble forms of amyloid beta (Aβ) for the treatment of Alzheimer’s disease (AD). The approval is based on Phase 2 data that demonstrated that LEQEMBI reduced the accumulation of Aβ plaque in the brain, a defining feature of Alzheimer's Disease.

Going to an area where there are a lot of wind vanes can be shocking. The noise and environmental blight for so little energy isn't worthwhile, and needing to get exemptions from endangered species laws due to deaths of avians like eagles make them a real negative. Solar panels have a little better cultural response but can still be unattractive. If you are a wealthy elite who doesn't like the appearance, or a government building using taxpayer funds, you may be able to turn architectural constraints into alternative energy without ruining the aesthetic. The archaeological park of Pompeii and the Portuguese city of Evora are creating solar panels that look like ancient Roman tiles or terracotta bricks to match the skyline.

Inscriptions on the walls and crosses in a grotto first found by grave robbers in Lachish national park of the Judean lowlands west of Jerusalem have led archaeologists to conclude it was dedicated to Salome, associated with the birth of Jesus Christ in early Christian accounts.  The Jewish burial chamber and ossuaries dating back to the Roman period became part of a Christian chapel during the Byzantine era until the region was captured by the Rashidun Caliphate in the middle of the 7th century.

From insulin to lowering environmental strain to grow food, genetic engineering is one of the marvels of the 20th century. In the 21st, CRISPR-Cas9 or something else may achieve the same lofty status but genetic engineering isn't done yet.

Giant blue and humpback whales migrate across the ocean to breed and give birth in waters where predators are scarce.A new analysis of the fossil bed in the Berlin-Ichthyosaur State Park (BISP) in Nevada’s Humboldt-Toiyabe National Forest suggests that nearly 200 million years before giant whales evolved, school bus-sized marine reptiles called ichthyosaurs may have been making similar migrations to breed and give birth together in relative safety.Nevada is east of the very large state of California, and the study offers a possible explanation why at least 37 of these marine reptiles came to meet their ends in the same locale.

The Donnan electric potential arises from an imbalance of charges at the interface of a charged membrane and a liquid but detecting it directly has not been possible. Until now.

Two years before SARS-CoV-2, the Alongshan (ALS) virus emerged in China. It was alarming because it was found to be a member of the flavivirus family along with the devastating tickborne encephalitis  (TBE) virus, which can cause inflammation of the brain and of the linings of the brain and spinal cord, and bacteria leading to the infectious Lyme disease (borreliosis). It was discovered after patients bitten by ticks suffered from fever and headaches, the typical symptoms of a TBE infection, but no antibodies against the TBE virus or its genetic material could be detected in the affected individuals. Instead, the researchers found a previously unknown RNA virus, the Alongshan virus.

List most planets, Earth was once a newly formed, sterile planet, so a philosophical and scientific question is, how did that change? Its randomness is the best argument for why we may be the most advanced civilization in this galaxy, if not the universe, and also the best argument for why we are not alone by now.For the over four billion years that our terra firma has been around, meteorites have been hurtling through the atmosphere at high speeds toward its surface. and some argue that resulting debris may have included carbonaceous chondrites — a class of meteorite whose members contain significant amounts of water and small molecules, such as amino acids - and could have contributed to the evolution of life on Earth. 

The most popular pets are cats and dogs but their origins as human companions are much different. Dogs became domesticated during the ice age 23,000 years ago as humans and wolves co-habitated in tolerable refuge areas. Scavenging and then feeding by humans led to companionship. Pet cats (Felis silvestris catus. Felis catus) are much more recent, and evidence shows they were allowed as pest control but gradually became companions as humans migrated and took cats with them. Like dogs, and unlike cattle and horses, there was a nexus for domestication; in the case of cats the Fertile Crescent, the areas of the Middle East surrounding the Tigris and Euphrates rivers.

To help try and understand the evolution and origins of cell motility, researchers have created the smallest mobile lifeform ever. Scientists introduced seven proteins, believed to be directly involved in allowing Spiroplasma bacteria to swim into a synthetic bacterium named syn3—through genetic engineering. syn3 was designed and chemically synthesized to have the smallest genomic DNA possible including the minimum essential genetic information required for growth from the smallest genomes of naturally occurring Mycoplasma bacteria.

A new study shows that supply chain cost increases coupled with inflation due to leaders just creating more currency are not new; they have been happening since ways to trade began.

A recent study revealed how the SARS-CoV-2 Spike (S)-protein interacts with human Estrogen Receptor Alpha (ERα) in lung tissue, which may increase the pro-coagulation activity of endothelial cells, enhancing the risk of thrombosis and shedding new light on the pathogenic mechanisms underlying SARS-CoV-2 infection and on its sex-specific differences. The authors say it may also lead to the severe coagulopathy observed in some people receiving the SARS-CoV-2 vaccine.