Researchers have created a programmable DNA thermometer that 20,000 times smaller than a human hair, using a discovery made 60 years ago - that DNA molecules that encode our genetic information can unfold when heated.
"In recent years, biochemists also discovered that biomolecules such as proteins or RNA (a molecule similar to DNA) are employed as nanothermometers in living organisms and report temperature variation by folding or unfolding," says senior author Prof. Alexis Vallée-Bélisle of the University of Montreal. "Inspired by those natural nanothermometers, which are typically 20,000x smaller than a human hair, we have created various DNA structures that can fold and unfold at specifically defined temperatures."