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How Researchers Teach Bacteria New Behaviors

How Researchers Teach Bacteria New Behaviors

Researchers working in the field of synthetic biology use components that occur in nature and combine them in a new way. This is how bacteria acquire functions that they hadn't previously possessed. This offers great potential for biotechnology.
Bacteria respond to temperature and metabolic products
Johanna Roßmanith and her doctoral supervisor Prof Dr Franz Narberhaus from the Chair of Microbial Biology carried out a successful study where they controlled the type of proteins a bacterium would manufacture and its behaviour. This is how they have made a bacterium swim that hadn't previously had the ability to move. The researchers made that possible by combining various modules from the bacterium's RNA in a new way.

Increases In Food Allergies Or Diagnoses? No Change In IgE Antibody Levels, Finds Study

Increases In Food Allergies Or Diagnoses? No Change In IgE Antibody Levels, Finds Study

There have been increases in prevalence of food allergies over the past several decades but a debate over why; some fundraising groups and websites claim it is due to science changing food while some say it is simply better diagnosis and others say it could be a changing relationship between the presence of food-specific immunoglobulin E (IgE) -- a blood marker associated with food allergy -- in children's blood between the 1980s and the 2000s.
A new study using 5,000 stored blood samples in the Journal of Allergy and Clinical Immunology found no increase in the presence of IgE.

High Doses Of Common Chemo Drug Methotrexate Limit Relapses Of Childhood Leukemia

High Doses Of Common Chemo Drug Methotrexate Limit Relapses Of Childhood Leukemia

With a cure rate approaching 90 percent, acute lymphoblastic leukemia (ALL), the most common type of childhood cancer, is one of the big "success stories" of modern cancer treatment.
Yet up to 20 percent of patients with a high risk of relapse are not cured, which could change with the results from a clinical trial showing that high doses of the commonly-used chemotherapy drug methotrexate increases the survival rate for these patients. 

Probiotics Protect Mice From Estrogen Deficiency-related Bone Loss

Probiotics Protect Mice From Estrogen Deficiency-related Bone Loss

After menopause, a decline in estrogen levels is linked to increases in inflammation that can cause osteoporosis. Intestinal bacteria have been shown to influence inflammation by modulating immune responses, and a new study suggests that differences in gut microbial populations may determine the extent of post-menopausal bone loss. In this month's issue of the JCI, a research team led by Roberto Pacifici at Emory University demonstrates a link between gut bacteria and the bone loss induced by estrogen deficiency. Mice lacking gut bacteria were protected against the estrogen deficiency-induced inflammation, gut permeability, and bone loss that occurred in mice with normal gut bacteria.

GI Problems In Autism May Originate In Genes, Study Suggests

GI Problems In Autism May Originate In Genes, Study Suggests

NEW YORK, NY (April 25, 2016)--Researchers at Columbia University Medical Center (CUMC) have found evidence in mice that, for some types of autism, gastrointestinal difficulties may originate from the same genetic changes that lead to the behavioral and social characteristics of the condition. The study was published in the Journal of Clinical Investigation.
Children with autism spectrum disorder are four times more likely to suffer from gastrointestinal problems than other children. These GI troubles are often blamed on the tendency of kids with autism to limit their diets to a few favored food items.

How Nature Disrupts Coral Reefs' Recycling

How Nature Disrupts Coral Reefs' Recycling

Coral reefs, the world's most productive and diverse marine ecosystems, rely on a recycling program to stay healthy: The corals and algae that form the base of the reef's food web release a variety of nutrients that support a complex and efficient food chain.
But when this system gets out of whack, the cycle breaks down and endangers the coral reef's health, and a new paper in Nature Microbiology explores how a process known as "microbialization" destroys links in this delicate food chain.

Why Is Visceral Fat Worse Than Subcutaneous Fat?

Why Is Visceral Fat Worse Than Subcutaneous Fat?

Researchers have long-known that visceral fat - the kind that wraps around the internal organs - is more dangerous than subcutaneous fat that lies just under the skin around the belly, thighs and rear. But how visceral fat contributes to insulin resistance and inflammation has remained unknown.
A study led by researchers at the University of Illinois at Chicago points blame at a regulatory molecule in cells called TRIP-Br2 that is produced in response to overeating's stress on the machinery cells use to produce proteins.
The findings are published in the journal Nature Communications.

Accutane: Despite Birth Defects Risk, 50 Percent Of Canadian Women Don't Comply With Requirements

Accutane: Despite Birth Defects Risk, 50 Percent Of Canadian Women Don't Comply With Requirements

Isotretinoin (popularly marketed as Accutane) is used to treat severe acne and has been approved in Canada since 1983. The average age of isotretinoin users in Canada is estimated to be 24 years, and half of all prescriptions are written for females, a concern because it can severely harm a fetus, causing craniofacial, cardiac and central nervous system defects, as well as a high likelihood of miscarriage or medical termination. 
Even Canada's program recommends informed written consent, two negative pregnancy tests before beginning treatment and the use of two reliable birth control methods during treatment, numerous studies in Canada and internationally have indicated poor adherence to pregnancy prevention guidelines among women taking isotretinoin. 

Life's Timekeeper: A Biochemical Oscillator Suggestion For Animal Evolution

Life's Timekeeper: A Biochemical Oscillator Suggestion For Animal Evolution

Some new speculation on animal (metazoan) evolution, suggesting that it was partly mediated through a biochemical oscillator (cycler), named Life's Timekeeper, present in all animal cells. The cycler controls cell maintenance and repair, thereby determining how long cells survive (longevity) and it originated in the single-celled ancestor of all animals, which had very short cell longevity.

Vitamin D Insufficiency, Low Rate Of DNA Methylation In Black Teens May Increase Disease Risk

Vitamin D Insufficiency, Low Rate Of DNA Methylation In Black Teens May Increase Disease Risk

AUGUSTA, Ga. - Low levels of vitamin D in black teens correlates with low activity of a major mechanism for controlling gene expression that may increase their risk of cancer and other disease, researchers report.
Their study measured vitamin D levels as well as levels of global DNA methylation in 454 healthy individuals age 14-18. In this group, 99 percent of the white teens had adequate vitamin D levels, 66 percent of the black teens were vitamin D-deficient and all the black teens had lower levels of methylation compared to their white peers, said Dr. Haidong Zhu, molecular geneticist at the Georgia Prevention Institute at the Medical College of Georgia at Augusta University.

Researchers Discover Fate Of Melting Glacial Ice In Greenland

Researchers Discover Fate Of Melting Glacial Ice In Greenland

Athens, Ga. - Over the past several decades, scientists have observed a significant increase in the melting of glacial land ice on the island of Greenland, spurring concerns about global sea level rise and the long-term effects of atmospheric warming. What has been less clear, however, is what happens to this meltwater once it enters the ocean.
Now, a team of researchers led by faculty at the University of Georgia has discovered the fate of much of the freshwater that pours into the surrounding oceans as the Greenland ice sheet melts every summer. They published their findings today in the journal Nature Geoscience.